Results 21 to 30 of about 5,041,480 (330)
PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception
Toxins, 2021 Crotalphine (CRP) is a structural analogue to a peptide that was first identified in the crude venom from the South American rattlesnake Crotalus durissus terrificus.
Bárbara G. de Freitas +6 more
doaj +1 more source
Cell Death Discovery, 2023 Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) protein.
Alba Sansa +6 more
doaj +1 more source
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer
npj Genomic Medicine, 2023 Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote ...
Ilya G. Serebriiskii +8 more
doaj +1 more source
Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells [PDF]
, 2016 Treatment of chronic myelogenous leukemia (CML) with BCR-ABL tyrosine kinase inhibitors (TKI) fails to eliminate leukemia stem cells (LSC). Patients remain at risk for relapse, and additional approaches to deplete CML LSC are needed to enhance the ...
Agarwal, Puneet +9 more
core +1 more source
Seminars in Immunology, 2006 Mammalian Toll-like receptors (TLRs) play a critical role in detection of invading pathogens as well as triggering of subsequent inflammatory and immune responses. Each TLR recognizes distinct microbial components and activates different signaling pathways by selective utilization of adaptor molecules.
Taro, Kawai, Shizuo, Akira
openaire +5 more sources
Nature Communications, 2016 N-docosahexaenoylethanolamine (synaptamide) promotes neurogenesis but the molecular mechanism involved is unknown. Here, the authors show that orphan G-protein coupled receptor 110 is the synaptamide receptor, with deletion in mice affecting development ...
Ji-Won Lee +8 more
doaj +1 more source
A homeostatic model of IκB metabolism to control constitutive NF‐κB activity
Molecular Systems Biology, 2007 Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease‐associated aberrant activity of the pathway is often due to misregulation of the equilibrium state.
Ellen L O'Dea +7 more
doaj +1 more source
Proteomes, 2015 Gaining insight into normal cellular signaling and disease biology is a critical goal of proteomic analyses. The ability to perform these studies successfully to extract the maximum value and discovery of biologically relevant candidate biomarkers is ...
Matthew P. Stokes +8 more
doaj +1 more source
Optimization of resource allocation can explain the temporal dynamics and honesty of sexual signals [PDF]
, 2009 In species in which males are free to dynamically alter their allocation to sexual signaling over the breeding season, the optimal investment in signaling should depend on both a male’s state and the level of competition he faces at any given time.
Blount, Jonathan D. +3 more
core +1 more source
The Signal for Signaling, Found
PLoS Pathogens, 2009 An important task in the life of bacteria is to influence their environment, which for commensal, symbiotic, and pathogenic bacteria also includes their hosts. This is done primarily by secreting various sets of proteins (effectors), either simply to the outside environment or directly into host cells.
Marcin Grynberg, Adam Godzik
openaire +4 more sources