Compensatory effects in the PI3K/PTEN/AKT signaling network following receptor tyrosine kinase inhibition [PDF]
, 2011 Overcoming de novo and acquired resistance to anticancer drugs that target signaling networks is a formidable challenge for drug design and effective cancer therapy.
Bown, James L. +5 more
core +4 more sources
A homeostatic model of IκB metabolism to control constitutive NF‐κB activity
Molecular Systems Biology, 2007 Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease‐associated aberrant activity of the pathway is often due to misregulation of the equilibrium state.
Ellen L O'Dea +7 more
doaj +1 more source
Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding [PDF]
, 2015 The role of the primary cilium in key signaling pathways depends on dynamic regulation of ciliary membrane protein composition, yet we know little about the motors or membrane events that regulate ciliary membrane protein trafficking in existing ...
Adair +63 more
core +3 more sources
Genome-wide screen for genes involved in Caenorhabditis elegans developmentally timed sleep [PDF]
, 2017 In Caenorhabditis elegans, Notch signaling regulates developmentally timed sleep during the transition from L4 larval stage to adulthood (L4/A) . To identify core sleep pathways and to find genes acting downstream of Notch signaling, we undertook the ...
Hart, Anne C +4 more
core +3 more sources
Proteomes, 2015 Gaining insight into normal cellular signaling and disease biology is a critical goal of proteomic analyses. The ability to perform these studies successfully to extract the maximum value and discovery of biologically relevant candidate biomarkers is ...
Matthew P. Stokes +8 more
doaj +1 more source
Is NO the Answer? The Nitric Oxide Pathway Can Support Bone Morphogenetic Protein 2 Mediated Signaling [PDF]
, 2019 The growth factor bone morphogenetic protein 2 (BMP2) plays an important role in bone development and repair. Despite the positive effects of BMP2 in fracture healing, its use is associated with negative side effects and poor cost effectiveness, partly ...
Bormann, Nicole +5 more
core +1 more source
The Signal for Signaling, Found
PLoS Pathogens, 2009 An important task in the life of bacteria is to influence their environment, which for commensal, symbiotic, and pathogenic bacteria also includes their hosts. This is done primarily by secreting various sets of proteins (effectors), either simply to the outside environment or directly into host cells.
Marcin Grynberg, Adam Godzik
openaire +4 more sources
Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans [PDF]
, 2019 Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose
daeeun jeong +5 more
core +1 more source
Trends in Biotechnology, 2014 Signaling pathways function as the information-passing mechanisms of cells. A number of databases with extensive manual curation represent the current knowledge base for signaling pathways. These databases motivate the development of computational approaches for prediction and analysis.
Anna, Ritz +4 more
openaire +2 more sources
A multi‐scale approach reveals that NF‐κB cRel enforces a B‐cell decision to divide
Molecular Systems Biology, 2015 Understanding the functions of multi‐cellular organs in terms of the molecular networks within each cell is an important step in the quest to predict phenotype from genotype.
Maxim N Shokhirev +6 more
doaj +1 more source