Results 61 to 70 of about 2,227,213 (269)

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death

Cell Death and Disease, 2020
Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce immune-mediated abscopal effects, resulting in regression of metastases, distant from the irradiated ...
Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele, Peter Vandenabeele   +13 more
doaj   +1 more source

The Signal in the Genomes

PLoS Computational Biology, 2006
Nostra culpa. Not only did we foist a hastily conceived and incorrectly executed simulation on an overworked RECOMB conference program committee, but worse—nostra maxima culpa—we obliged a team of high-powered researchers to clean up after us! It was never our intention to introduce an alternative way of constructing synteny blocks; the so-called ST ...
openaire   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Cysteine availability tunes ubiquitin signaling via inverse stability of LRRC58 E3 ligase and its substrate CDO1

Nature Communications
Cellular responses to amino acid fluctuations often hinge on ubiquitin-mediated control of metabolic enzymes, yet the underlying E3 ligase pathways remain poorly defined.
Gisele A. Andree, Luca J. Stier, Kerstin Schmiederer, Alina S. Thielen, Luis Schmid, Samuel A. Maiwald, Karthik V. Gottemukkala, Jiale Du, Susanne von Gronau, Claudia Strasser, Judith Müller, Lukas T. Henneberg, Camille Guyot, Gary Kleiger, Matthias Mann, Peter J. Murray, Brenda A. Schulman   +16 more
doaj   +1 more source

Loss of TET2 and TET3 in regulatory T cells unleashes effector function

Nature Communications, 2019
Loss of TET proteins in immune cell populations is known to result in immunopathology. Here the authors show that deficiency of Tet2 and Tet3 proteins, specifically in the CD4+ FoxP3+ Treg lineage, results in a dominant pathology in which ex-Treg cells ...
Xiaojing Yue, Chan-Wang J. Lio, Daniela Samaniego-Castruita, Xiang Li, Anjana Rao   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Metabolic sexual dimorphism in hypothalamic Fezf1 neuron-specific BDNF knockout

Biology of Sex Differences
Background Brain-derived neurotrophic factor (BDNF) is highly expressed in the hypothalamus where it exerts regulatory functions over neurogenesis, reproduction, energy balance, and metabolism.
Dayana Cabral-da-Silva, Ariane M. Zanesco, Fernando Valdivieso-Rivera, Ana L. Gallo-Ferraz, Marcela R. Simões, Bruna Bombassaro, Carlos H. Sponton, Licio A. Velloso   +7 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source