Results 81 to 90 of about 3,216,633 (318)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Robust Deviations from Signaling Equilibria [PDF]

In Sender-Receiver games with costly signaling, some equilibria are vulnerable to deviations which could be "unambiguously" interpreted by the Receiver as coming from a unique set of possible Sender-types.
Peter Eso, James Schummer
core  

A Review on Notch Signaling and Colorectal Cancer

, 2020
Colorectal cancer (CRC) has one of the highest mortality rates despite the advancement of treatment options. Aggressive CRC remains difficult to treat owing to the activation of oncogenic signaling pathways such as the Notch signaling pathway.
Arun K. Sharma, Chendil Damodaran, Ashish Tyagi   +2 more
core   +1 more source

A Preliminary Study on 2D Convolutional Neural Network-Based Discontinuous Rail Position Classification for Detection on Rail Breaks Using Distributed Acoustic Sensing Data

IET Electrical Systems in Transportation
Rail breaks, which are crucial maintenance issues for the railways, require immediate inspection and maintenance as it can cause severe railway accidents. Though, it is still difficult to promptly detect rail breaks that occur during train operation even
Hye-Yeun Chun, Jungtai Kim, Dongkue Kim, Ilmu Byun, Kyeongjun Ko   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Signaling Credit Risk in Agriculture: Implications for Capital Structure Analysis [PDF]

Signaling is an important element in the lender-borrower relationship that influences the cost and availability of debt capital to agricultural borrowers.
Barry, Peter J., Katchova, Ani L., Zhao, Jianmei   +2 more
core  

Establishment and genomic validation of novel patient-derived xenograft models for drug discovery in gastrointestinal stromal tumor

BMC Cancer
Most gastrointestinal stromal tumor (GIST) patients develop clinical resistance to approved tyrosine kinase inhibitors (TKI). The development of effective treatment strategies for refractory GIST requires identification of novel targets for ...
Marya Kozinova, Ashot Nazaretian, Martin G. Belinsky, Yan Zhou, Shalina Joshi, Karthik Devarajan, Kathy Q. Cai, Delia Zumpano, Shuai Ye, Yinfei Tan, Sanjay S. Reddy, Jeffrey M. Farma, Margaret von Mehren, Lori Rink   +13 more
doaj   +1 more source

The Signal in the Genomes

PLoS Computational Biology, 2006
Nostra culpa. Not only did we foist a hastily conceived and incorrectly executed simulation on an overworked RECOMB conference program committee, but worse—nostra maxima culpa—we obliged a team of high-powered researchers to clean up after us! It was never our intention to introduce an alternative way of constructing synteny blocks; the so-called ST ...
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source