Results 71 to 80 of about 3,216,633 (318)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Multimodal substrate recruitment enables CTLHMKLN1 E3 ligase to target acetylated N-, C-, and internal degrons

Nature Communications
The GID/CTLH family of E3 ubiquitin ligases employs several substrate receptor subunits that recruit distinct degrons, but the substrate recognition mechanisms of the CTLHMKLN1 assembly have largely remained elusive.
Sara Sepic, Karthik V. Gottemukkala, Jiale Du, Samuel A. Maiwald, Jakub Chrustowicz, Eleftheria C. Papadopoulou, Luca J. Stier, Susanne von Gronau, Brenda A. Schulman   +8 more
doaj   +1 more source

A20 deubiquitinase controls PGC-1α expression in the adipose tissue

Lipids in Health and Disease, 2018
Background Peroxisome proliferator-activated receptor γ coactivator- 1alpha (PGC-1α) plays an important role in whole body metabolism and, particularly in glucose homeostasis.
Bruna Bombassaro, Leticia M. Ignacio-Souza, Carla E. Nunez, Daniela S. Razolli, Rafael M. Pedro, Andressa Coope, Eliana P. Araujo, Elinton A. Chaim, Licio A. Velloso   +8 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Signaling in deterministic and stochastic settings [PDF]

We contrast a standard deterministic signaling game with one where the signal-generating mechanism is stochastic. With stochastic signals a unique equilibrium emerges that involves separation and has intuitive comparative-static properties as the degree ...
Jeitschko, Thomas D., Normann, Hans-Theo
core  

GEFs:Dual regulation of Rac1 signaling [PDF]

, 2016
GEFs play a critical role in regulating Rac1 signaling. They serve as signaling nodes converting upstream signals into downstream Rac1-driven cellular responses.
Hadir Marei1, Malliri, Angeliki, Malliri, Angeliki; id_orcid, Marei, Hadir   +3 more
core   +1 more source

Systematic analysis of the intersection of disease mutations with protein modifications

BMC Medical Genomics, 2019
Background Perturbed posttranslational modification (PTM) landscapes commonly cause pathological phenotypes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors allowing the identification of spontaneous cancer-driving mutations, while ...
Claire M. Simpson, Bin Zhang, Peter V. Hornbeck, Florian Gnad   +3 more
doaj   +1 more source

Selling signals

Journal of Economic Theory, 2019
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Spence Revisited: Signaling and the Allocation of Individuals to Jobs [PDF]

Spence (1974a) considered a variant of his signaling model in which there are two types of jobs, and in which signaling can increase wealth by improving the allocation of individuals to jobs.
Timothy Perri
core