Results 51 to 60 of about 3,216,633 (318)

Adaptive oncogenesis of β-catenin emerges from declining liver tissue integrity

Nature Communications
Mutations are fundamental to oncogenesis, yet they cannot fully explain cancer progression, as oncogenic mutations frequently accumulate in healthy tissues without immediate malignancy.
Abhinav Illendula, Charles K. Hewett, Yuki Hayata, Lauren S. Strathearn, Guoshun He, Laia Carballo-Botinas, Sara Navas-Sanz, Maria Niqui-Capdevila, Avril Garcia-Santos, Rocío Bernabé-Pérez, Alejandra Bustillo-Bustos, Ani Mikoyan, Eleanor Helm, Marina Gonzalez-Sorribes, Nicola de Prisco, Aasthika Das, Yuanguangyan Zhang, David Rossell, Michael Slifker, Naiara Akizu, Beicheng Sun, Joan Font-Burgada   +21 more
doaj   +1 more source

Calcium signaling [PDF]

Cell, 1995
Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles.
openaire   +3 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]

, 2012
Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Ruiz-Heinrich, Lourdes, Peröbner, Iris, Capovilla, Simon, Neth, Peter, Fernsebner, Katharina, Lechner, F., Jochum, M., Neth, P., Kolben, Thomas, Geissler, Claudia, Fernsebner, K., Geissler, C., Perobner, I., Peroebner, Iris, Jochum, Marianne, Lechner, Felix, Ruiz-Heinrich, L., Kolben, T., Capovilla, S.   +18 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

bence-szalai/gpcr-signaling-simulation: Science Signaling revision

, 2023
<p>Code version as submitted for revision at Science Signaling.</p ...
gargerd, Bence Szalai
core   +1 more source

The intracellular localization and the ionic permeation of TRPV6 triggers chronic pancreatitis, skeletal dysplasia and is connected to mucolipidosis type II

Cell Communication and Signaling
Heterozygous TRPV6 mutations, which reduce significantly the Ca2+-permeability of the channel, lead to chronic pancreatitis and, if both TRPV6-alleles are affected, to skeletal dysplasia with neonatal transient hyperparathyroidism (TNHP) of newborns.
Claudia Fecher-Trost, Anna-Lena Gehl, Alessa Trunk, Johanna Hellmich, Christine Wesely, Heidi Löhr, Stefanie Buchholz, Marnie Cole, Andreas Beck, Markus R. Meyer, Ulrich Wissenbach   +10 more
doaj   +1 more source

The mechanical phenotypic plasticity of melanoma cell: an emerging driver of therapy cross-resistance

Oncogenesis, 2023
Advanced cutaneous melanoma is the deadliest form of skin cancer and one of the most aggressive human cancers. Targeted therapies (TT) against BRAF mutated melanoma and immune checkpoints blockade therapies (ICB) have been a breakthrough in the treatment
Serena Diazzi, Sophie Tartare-Deckert, Marcel Deckert   +2 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source