Results 31 to 40 of about 5,103,566 (350)
Nature Communications, 2022 Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges +8 more
doaj +1 more source
Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases
Cell Death and Disease, 2022 Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the controlled induction of cell death are the Death Receptors (DR).
Vesna Risso +2 more
doaj +1 more source
PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception
Toxins, 2021 Crotalphine (CRP) is a structural analogue to a peptide that was first identified in the crude venom from the South American rattlesnake Crotalus durissus terrificus.
Bárbara G. de Freitas +6 more
doaj +1 more source
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]
, 2018 The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis +5 more
core +2 more sources
Cell Death Discovery, 2023 Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) protein.
Alba Sansa +6 more
doaj +1 more source
Information transfer in signaling pathways : a study using coupled simulated and experimental data [PDF]
, 2008 Background: The topology of signaling cascades has been studied in quite some detail. However, how information is processed exactly is still relatively unknown.
Pahle, Jürgen +3 more
core +5 more sources
Seminars in Immunology, 2006 Mammalian Toll-like receptors (TLRs) play a critical role in detection of invading pathogens as well as triggering of subsequent inflammatory and immune responses. Each TLR recognizes distinct microbial components and activates different signaling pathways by selective utilization of adaptor molecules.
Taro, Kawai, Shizuo, Akira
openaire +5 more sources
Nature Communications, 2016 N-docosahexaenoylethanolamine (synaptamide) promotes neurogenesis but the molecular mechanism involved is unknown. Here, the authors show that orphan G-protein coupled receptor 110 is the synaptamide receptor, with deletion in mice affecting development ...
Ji-Won Lee +8 more
doaj +1 more source
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer
npj Genomic Medicine, 2023 Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote ...
Ilya G. Serebriiskii +8 more
doaj +1 more source
A Journey from Improper Gaussian Signaling to Asymmetric Signaling
, 2020 The deviation of continuous and discrete complex random variables from the traditional proper and symmetric assumption to a generalized improper and asymmetric characterization (accounting correlation between a random entity and its complex conjugate ...
Alouini, Mohamed-Slim +3 more
core +1 more source