Results 11 to 20 of about 2,227,213 (269)
Loss of Pkd1 limits susceptibility to colitis and colorectal cancer
Oncogenesis, 2023 Colorectal cancer (CRC) is one of the most common cancers, with an annual incidence of ~135,000 in the US, associated with ~50,000 deaths. Autosomal dominant polycystic kidney disease (ADPKD), associated with mutations disabling the PKD1 gene, affects as
Anna S. Nikonova +10 more
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Cell Death Discovery, 2021 A Correction to this paper has been published: https://doi.org/10.1038/s41420-021-00445 ...
Farai C. Gombedza +3 more
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Nature Communications, 2022 Inducible disruption of TET dioxygenases in mouse embryonic stem cells results in chromosome mis-segregation and aneuploidies, due to Khdc3 downregulation suggesting a role for TET enzymes and DNA methylation patterns in maintaining genome stability.
Romain O. Georges +8 more
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Mechanodetection of neighbor plants elicits adaptive leaf movements through calcium dynamics
Nature Communications, 2023 Plants detect their neighbors via various cues, including reflected light and touching of leaf tips, which elicit upward leaf movement (hyponasty). It is currently unknown how touch is sensed and how the signal is transferred from the leaf tip to the ...
Chrysoula K. Pantazopoulou +7 more
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SSRN Electronic Journal, 2010 Awards are widespread in all countries and are prevalent both in the public sphere and in the private sector. This paper argues, and empirically supports, that awards serve public functions and economists should take them seriously. Using a unique cross-country data set, we suggest that awards serve as signals.
Frey, Bruno S, Neckermann, Susanne
openaire +5 more sources
Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases
Cell Death and Disease, 2022 Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the controlled induction of cell death are the Death Receptors (DR).
Vesna Risso +2 more
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PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception
Toxins, 2021 Crotalphine (CRP) is a structural analogue to a peptide that was first identified in the crude venom from the South American rattlesnake Crotalus durissus terrificus.
Bárbara G. de Freitas +6 more
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Cell Death Discovery, 2023 Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) protein.
Alba Sansa +6 more
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Nature Communications, 2016 N-docosahexaenoylethanolamine (synaptamide) promotes neurogenesis but the molecular mechanism involved is unknown. Here, the authors show that orphan G-protein coupled receptor 110 is the synaptamide receptor, with deletion in mice affecting development ...
Ji-Won Lee +8 more
doaj +1 more source
Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer
npj Genomic Medicine, 2023 Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote ...
Ilya G. Serebriiskii +8 more
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