Results 21 to 30 of about 2,227,213 (269)
A homeostatic model of IκB metabolism to control constitutive NF‐κB activity
Molecular Systems Biology, 2007 Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease‐associated aberrant activity of the pathway is often due to misregulation of the equilibrium state.
Ellen L O'Dea +7 more
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Proteomes, 2015 Gaining insight into normal cellular signaling and disease biology is a critical goal of proteomic analyses. The ability to perform these studies successfully to extract the maximum value and discovery of biologically relevant candidate biomarkers is ...
Matthew P. Stokes +8 more
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Signal transduction and signaling networks
Molecular Biology of the Cell, 2013 Cellular signaling can be complex and dynamic. In the past several decades, it has become clear that many signal transduction pathways are not simple one-way transmissions of upstream stimuli, but are mediated through extremely complicated networks. Our next challenge is to move beyond the static biochemical description of networks into developing a ...
Ikeda, Fumiyo, Lahav, Galit
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Proceedings 2003 IEEE Information Theory Workshop (Cat. No.03EX674), 2004 Motivated by signal processing, we present a new class of channel codes, called signal codes, for continuous-alphabet channels. Signal codes are lattice codes whose encoding is done by convolving an integer information sequence with a fixed filter pattern.
Ofir Shalvi, Naftali Sommer, Meir Feder
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A multi‐scale approach reveals that NF‐κB cRel enforces a B‐cell decision to divide
Molecular Systems Biology, 2015 Understanding the functions of multi‐cellular organs in terms of the molecular networks within each cell is an important step in the quest to predict phenotype from genotype.
Maxim N Shokhirev +6 more
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Cell Death Discovery, 2022 Ferroptosis is a caspase-independent form of regulated cell death strongly linked to the accumulation of reactive lipid hydroperoxides. Lipid hydroperoxides are neutralized in cells by glutathione peroxidase 4 (GPX4) and inhibitors of GPX4 are potent ...
Tanu Singh +2 more
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Cellular MicrobiologyTrial Registration: ClinicalTrials.gov identifier: NCT01473524 ...
Gayatri Reghu +3 more
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Automated single-molecule imaging in living cells
Nature Communications, 2018 Large scale live cell screens often lack single-molecule resolution. Here the authors present an artificial intelligence-assisted TIRF microscope with automated cell searching and focusing, and use it for high-throughput single-molecule imaging of EGFR ...
Masato Yasui +4 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare pediatric CD30‐positive T‐cell lymphoproliferative disorder with an excellent prognosis, but its genomic drivers are poorly defined. We report three children with skin‐limited disease demonstrating striking molecular heterogeneity, including NPM::ALK, NUP214::FRK, and a novel ...
Shoshana Greenberger +7 more
wiley +1 more source
Cold Spring Harbor Perspectives in Biology, 2012 Hedgehog (Hh) proteins constitute one family of a small number of secreted signaling proteins that together regulate multiple aspects of animal development, tissue homeostasis and regeneration. Originally uncovered through genetic analyses in Drosophila, their subsequent discovery in vertebrates has provided a paradigm for the role of morphogens in ...
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