Results 21 to 30 of about 862,938 (269)
Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases
Cell Death and Disease, 2022 Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the controlled induction of cell death are the Death Receptors (DR).
Vesna Risso +2 more
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PKCζ-Mitogen-Activated Protein Kinase Signaling Mediates Crotalphine-Induced Antinociception
Toxins, 2021 Crotalphine (CRP) is a structural analogue to a peptide that was first identified in the crude venom from the South American rattlesnake Crotalus durissus terrificus.
Bárbara G. de Freitas +6 more
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Nature Communications, 2016 N-docosahexaenoylethanolamine (synaptamide) promotes neurogenesis but the molecular mechanism involved is unknown. Here, the authors show that orphan G-protein coupled receptor 110 is the synaptamide receptor, with deletion in mice affecting development ...
Ji-Won Lee +8 more
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Cell Death Discovery, 2023 Spinal Muscular Atrophy (SMA) is a severe genetic neuromuscular disorder that occurs in childhood and is caused by misexpression of the survival motor neuron (SMN) protein.
Alba Sansa +6 more
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Signal transduction and signaling networks
Molecular Biology of the Cell, 2013 Cellular signaling can be complex and dynamic. In the past several decades, it has become clear that many signal transduction pathways are not simple one-way transmissions of upstream stimuli, but are mediated through extremely complicated networks. Our next challenge is to move beyond the static biochemical description of networks into developing a ...
Ikeda, Fumiyo, Lahav, Galit
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Specification of BMP signaling [PDF]
, 2019 Bone Morphogenetic Proteins (BMPs) together with the Growth and Differentiation Factors (GDFs) form the largest subgroup of the Transforming Growth Factor (TGF)β family and represent secreted growth factors, which play an essential role in many aspects ...
Mueller, Thomas D. +3 more
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A homeostatic model of IκB metabolism to control constitutive NF‐κB activity
Molecular Systems Biology, 2007 Cellular signal transduction pathways are usually studied following administration of an external stimulus. However, disease‐associated aberrant activity of the pathway is often due to misregulation of the equilibrium state.
Ellen L O'Dea +7 more
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Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer
npj Genomic Medicine, 2023 Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote ...
Ilya G. Serebriiskii +8 more
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A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways
, 2018 Mitochondrial dysfunctions activate retrograde signaling from mitochondria to the nucleus. To identify transcription factors and their associated pathways that underlie mitochondrial retrograde signaling, we performed gene expression profiling of the ...
Sehyun Chae +7 more
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Proceedings 2003 IEEE Information Theory Workshop (Cat. No.03EX674), 2004 Motivated by signal processing, we present a new class of channel codes, called signal codes, for continuous-alphabet channels. Signal codes are lattice codes whose encoding is done by convolving an integer information sequence with a fixed filter pattern.
Ofir Shalvi, Naftali Sommer, Meir Feder
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