Results 91 to 100 of about 403,629 (240)

The signaling effect of tax policy. [PDF]

The paper focuses on the signaling value of a tax when agents are less informed than the government on the effect of their consumption. The policy making process is analyzed as a game in which the government wants to influence consumers' behaviors ...
Barigozzi, Francesca, Villeneuve, Bertrand   +1 more
core  

Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization

Cell Communication and Signaling
Background The human CXC chemokine receptor 2 (CXCR2) is a G protein-coupled receptor (GPCR) interacting with multiple chemokines (i.e., CXC chemokine ligands CXCL1-3 and CXCL5-8). It is involved in inflammatory diseases as well as cancer.
Katrijn Boon, Nathan Vanalken, Martyna Szpakowska, Andy Chevigné, Dominique Schols, Tom Van Loy   +5 more
doaj   +1 more source

To Be Biased or Not to Be: A Play for G-Protein Coupled Receptors

International Journal of Translational Medicine
G protein-coupled receptors (GPCRs) are the largest family of diverse receptors in eukaryotic organisms, playing a critical role in modulating human physiology. It therefore comes as no surprise that about 36% of all currently available drugs target this
Nikitas G. Liolitsas, Evangelia Pantazaka, Evangelia Papadimitriou   +2 more
doaj   +1 more source

Heteroreceptor complexes and their allosteric receptor-receptor interactions in the central nervous system. Focus on examples from Dopamine D2 and Serotonin 5-HT1a receptors [PDF]

, 2018
GPCR interacting proteins (specially β- arrestin) and their receptor-protein interactions are also covered but their interactions with the allosteric receptor-receptor interactions in heteroreceptor complexes remain to be elucidated.
Corrales Ferro, Fidel
core   +1 more source

Ligand-Induced Biased Activation of GPCRs: Recent Advances and New Directions from In Silico Approaches

Molecules
G-protein coupled receptors (GPCRs) are the largest family of membrane proteins engaged in transducing signals from the extracellular environment into the cell.
Shaima Hashem, Alexis Dougha, Pierre Tufféry   +2 more
doaj   +1 more source

AP2σ Mutations Impair Calcium-Sensing Receptor Trafficking and Signaling, and Show an Endosomal Pathway to Spatially Direct G-Protein Selectivity

Cell Reports, 2018
Spatial control of G-protein-coupled receptor (GPCR) signaling, which is used by cells to translate complex information into distinct downstream responses, is achieved by using plasma membrane (PM) and endocytic-derived signaling pathways.
Caroline M. Gorvin, Angela Rogers, Benoit Hastoy, Andrei I. Tarasov, Morten Frost, Silvia Sposini, Asuka Inoue, Michael P. Whyte, Patrik Rorsman, Aylin C. Hanyaloglu, Gerda E. Breitwieser, Rajesh V. Thakker   +11 more
doaj   +1 more source

Characterization of forehead blood flow bias on NIRS signals during neural activation with a verbal fluency task

, 2022
Akitoshi Seiyama, Tatsuro Miura, Yuji Sasaki, Sayaka Okahashi, Nami Konishi, Monte Cassim   +5 more
openalex   +1 more source

Biased adult sex ratios in Western Europe populations of Little BustardTetrax tetraxas a potential warning signal of unbalanced mortalities [PDF]

, 2022
Eva Serrano‐Davies, Juán Traba, Beatriz Arroyo, François Mougeot, Francesc Cuscó, Santi Mañosa, Gérard Bota, Nuno Faria, Alexandre Villers, Fabián Casas, Carole Attié, Pierrick Devoucoux, Vincent Bretagnolle, Manuel B. Morales   +13 more
openalex   +1 more source

Morphogen Transport in Epithelia

, 2006
We present a general theoretical framework to discuss mechanisms of morphogen transport and gradient formation in a cell layer. Trafficking events on the cellular scale lead to transport on larger scales. We discuss in particular the case of transcytosis
B. Houchmandzadeh, D. A. Lauffenburger, F. Jülicher, H. Meinhardt, K. Kruse, M. González-Gaitán, P. Pantazis, S. Morimura, T. Bollenbach   +8 more
core   +1 more source

TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses

Cell Reports, 2018
Summary: The multi-ligand endocytic receptor, low-density lipoprotein-receptor-related protein 1 (LRP1), has anti-inflammatory roles in disease. Here, we reveal that pathogen-activated Toll-like receptors (TLRs) activate LRP1 in human and mouse primary ...
Lin Luo, Adam A. Wall, Samuel J. Tong, Yu Hung, Zhijian Xiao, Abdullah A. Tarique, Peter D. Sly, Emmanuelle Fantino, María-Paz Marzolo, Jennifer L. Stow   +9 more
doaj   +1 more source