Results 101 to 110 of about 403,629 (240)
CellsBackground: Metabolic dysfunction-associated liver disease (MASLD) and alcohol-associated liver disease (ALD) are among the leading causes of liver disease worldwide. The exact roles of epigenetic factors in both diseases remains largely unknown. In this
Daniela Stols-Gonçalves +7 more
doaj +1 more source
Forward Guidance for Monetary Policy: Is It Desirable? [PDF]
In this paper we assess whether forward guidance for monetary policy regarding the future path of interest rates is desirable. We distinguish between two cases where forward guidance for monetary policy may be helpful.
Hans Gersbach, Volker Hahn
core
Carrier phase bias estimation of geometry-free linear combination of GNSS signals for ionospheric TEC modeling [PDF]
, 2018 Anna Krypiak‐Gregorczyk +1 more
openalex +1 more source
Ultra-purification of Lipopolysaccharides reveals species-specific signalling bias of TLR4: importance in macrophage function [PDF]
, 2021 Matthew Stephens +2 more
openalex +1 more source
Designing signaling environments to steer transcriptional diversity in neural progenitor cell populations [PDF]
, 2019 Stem cell populations within developing embryos are diverse, composed of many different subpopulations of cells with varying developmental potential. The structure of stem cell populations in cell culture remains poorly understood and presents a barrier ...
Chen, Sisi +4 more
core
Teaching an Old Drug New Tricks: Agonism, Antagonism, and Biased Signaling of Pilocarpine through M3 Muscarinic Acetylcholine Receptor [PDF]
, 2017 Alexey Pronin +2 more
openalex +1 more source
Quantifying Signaling Bias: A Simple Approach to Quantify Functional Selectivity and Agonist Bias
The FASEB Journal, 2015 Interest in GPCR ligand bias has increased in recent years due to evidence that positive and negative aspects of drug activity can be due to differential pathway signaling. As a result it is possible to develop drugs with reduced side effects by enhancing positive effects by favoring one pathway over another.
Neil Charter, Lakshmi Anantharaman
openaire +1 more source
Simplicity of Completion Time Distributions for Common Complex Biochemical Processes
, 2009 Biochemical processes typically involve huge numbers of individual reversible steps, each with its own dynamical rate constants. For example, kinetic proofreading processes rely upon numerous sequential reactions in order to guarantee the precise ...
Brian Munsky +4 more
core +1 more source