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Flavors of GPCR signaling bias
NeuropharmacologyGPCRs are inherently flexible molecules existing in an equilibrium of multiple conformations. Binding of GPCR agonists shifts this equilibrium. Certain agonists can increase the fraction of active-like conformations that predispose the receptor to coupling to a particular signal transducer or a select group of transducers.
Mohammad Seyedabadi +1 more
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Phase retrieval with signal bias
Journal of the Optical Society of America A, 2009The effect of a uniform measurement bias, due to background light, stray light, detector dark current, or detector offset, on phase retrieval wavefront sensing algorithms is analyzed. Simulation results indicate that the root-mean-square error of the retrieved phase can be more sensitive to an unaccounted-for signal bias than to random noise in ...
Samuel T, Thurman, James R, Fienup
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Measurement of Receptor Signaling Bias
Current Protocols in Pharmacology, 2016AbstractG protein–coupled receptors (GPCRs) are often pleiotropically linked to numerous cellular signaling mechanisms in cells, and it is now known that many agonists differentially activate some signaling pathways at the expense of others. The mechanism for this effect is the stabilization of different active receptor states by different agonists ...
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Signaling bias in drug discovery
Expert Opinion on Drug Discovery, 2017The availability of different functional pharmacological assays has revealed that agonists for receptors that are pleiotropically coupled to multiple signaling pathways in the cell can emphasize signals to some pathways over others, i.e. can be biased toward certain signals.
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Receiver bias for colourful signals
Animal Behaviour, 2003Animals tend to respond more strongly to signals that are more colourful and such signals are also common in nature.
Liselotte Jansson, Magnus Enquist
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Temporal Bias: Time-Encoded Dynamic GPCR Signaling [PDF]
Trends in Pharmacological Sciences, 2017 Evidence suggests that cells can time-encode signals for secure transport and perception of information, and it appears that this dynamic signaling is a common principle of nature to code information in time. G-protein-coupled receptor (GPCR) signaling networks are no exception as their composition and signal transduction appear temporally flexible. In
Manuel Grundmann, Evi Kostenis
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Conflict, receiver bias and the evolution of signal form
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1995Abstract In a model, conflicts of interest between communicating individuals are shown to have an important influence on the cost and form of signals that evolve. Two types of conflict are considered: competition between senders to obtain a response from the receiver, and conflict between the sender and the receiver.
A, Arak, M, Enquist
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Modeling of Bias for the Analysis of Receptor Signaling in Biochemical Systems
Biochemistry, 2012 Ligand bias is a recently introduced concept in the receptor signaling field that underlies innovative strategies for targeted drug design. Ligands, as a consequence of conformational selectivity, produce signaling bias in which some downstream biochemical pathways are favored over others, and this contributes to variability in physiological ...
Larry S Barak, Sean Peterson
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Science, 2018
GPCR Signaling G protein–coupled receptors (GPCRs) can mediate signaling through the G protein or β-arrestin pathways. Drugs that selectively activate one of these pathways provide effective treatment without side effects. GPCRs must undergo phosphorylation mediated by the GPCR kinase (GRK) family of kinases to recruit β-arrestins.
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GPCR Signaling G protein–coupled receptors (GPCRs) can mediate signaling through the G protein or β-arrestin pathways. Drugs that selectively activate one of these pathways provide effective treatment without side effects. GPCRs must undergo phosphorylation mediated by the GPCR kinase (GRK) family of kinases to recruit β-arrestins.
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Estimation bias variation on beamformed signals
IEEE Transactions on Antennas and Propagation, 1995Digital beamforming is widely used for estimating the direction of arrival (DOA) of signals incident on an array of antennas. It is well known that conventional beamforming has limited spatial resolution determined by the aperture of the array. It is also known that multiple signals incident on the array "bias" the DOA estimates of every other incident
M.A. Zatman +3 more
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