Results 281 to 290 of about 8,752,965 (357)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Kremen2 Promotes Colorectal Cancer Progression by Activating the EGFR/JAK2/STAT3 Signaling Pathway. [PDF]

Iran J Biotechnol
Xue X, Zhang S, Sun X.
europepmc   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Hydrogen-Mediated Activation of the Nrf2/HO-1 Signaling Pathway Improves Cognitive Impairment in Sleep-Deprived Mice. [PDF]

CNS Neurosci Ther
Xiao Q, Zhou S, Tang B, Zhu Y.
europepmc   +1 more source

Role of the Wnt/β-catenin signaling pathway in the development of HCC. [PDF]

Front Immunol
Lin B, Li M.
europepmc   +1 more source

MiR-424-5p acts as an oncogene in Hep3B cells by activating the PI3K/AKT signaling pathway. [PDF]

Front Oncol
Ding Z, Qi S, Hu M, Wang L, Tang Y, Sun J, Zheng L, Li Y, Li L, Ma Q, Tang H.   +10 more
europepmc   +1 more source

Irisin activates the AMPK-Beclin1 signaling pathway to regulate pulmonary autophagy induced by CSE + LPS. [PDF]

Sci Rep
Chen Z, Wu S, Bai Z, Sun T, Ma C, Chen Y, Jiang P, Meng A.   +7 more
europepmc   +1 more source

Formononetin ameliorates SP-induced urticaria in mice via suppressing TAK1/MAK signaling pathway. [PDF]

PLoS One
Wu Y, Li C.
europepmc   +1 more source