Results 311 to 320 of about 8,752,965 (357)

Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway.

International Immunopharmacology, 2020
Acute lung injury (ALI) is a common acute respiratory disease treated in the clinic. Intestinal microflora disorder affect lung diseases through the gut-lung axis.
Jia-feng Tang, Lingqi Xu, Yiwen Zeng, Fang Gong   +3 more
semanticscholar   +1 more source

Signal Transduction: Just another signalling pathway

Current Biology, 1994
The recently identified JAK-STAT signal transduction pathway plays a major role in signalling the arrival of cytokines at the cell surface and can, in part, account for the pleiotropic and redundant effects of cytokines.
J, Briscoe, D, Guschin, M, Müller
openaire   +2 more sources

Non-Smad signaling pathways

Cell and Tissue Research, 2011
Transforming growth factor-beta (TGFβ) is a key regulator of cell fate during embryogenesis and has also emerged as a potent driver of the epithelial-mesenchymal transition during tumor progression. TGFβ signals are transduced by transmembrane type I and type II serine/threonine kinase receptors (TβRI and TβRII, respectively). The activated TβR complex
Yabing, Mu, Shyam Kumar, Gudey, Maréne, Landström   +2 more
openaire   +2 more sources

The Ethylene Signaling Pathway

Science, 2004
Plants use a structurally very simple gas molecule, the hydrocarbon ethylene, to modulate various developmental programs and coordinate responses to a multitude of external stress factors. How this simple molecule generates such a diverse array of effects has been the subject of intense research for the past two decades.
Jose M, Alonso, Anna N, Stepanova
openaire   +2 more sources

Insulin signal transduction pathways

Trends in Endocrinology & Metabolism, 1994
Insulin initiates its pleiotropic effects by activating the insulin receptor tyrosine kinase to phosphorylate several intracellular proteins. Recent studies have demonstrated that phosphotyrosine residues bind specifically to proteins that contain src homology 2 (SH2) domains, and that this interaction mediates the regulation of multiple intracellular ...
M J, Quon, A J, Butte, S I, Taylor
openaire   +2 more sources

Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease

Neurochemistry International, 2020
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases. Its major pathological hallmarks, neurofibrillary tangles (NFT), and amyloid-β plaques can result from dysfunctional insulin signaling.
Ansab Akhtar, S. P. Sah
semanticscholar   +1 more source

Cytokine receptor signaling pathways

Journal of Allergy and Clinical Immunology, 2000
Cytokines represent a diverse group of molecules that transmit intercellular signals. These signals may either be autocrine (where the same cell both produces the cytokine and responds to it) or paracrine (where the cytokine is made by one cell and acts on another). Both these situations can occur simultaneously.
W J, Leonard, J X, Lin
openaire   +2 more sources

Polyphenols: Novel Signaling Pathways

Current Pharmaceutical Design, 2018
Background: Cardiovascular disease (CVD) is currently the leading cause of death globally. The metabolic syndrome (MetS), a clustering of risk factors including hypertension, hyperglycemia, elevated low-density lipoprotein (LDL) cholesterol, reduced high-density lipoprotein (HDL) cholesterol and increased visceral adiposity, is a significant risk ...
Marie-Louise, Ricketts, Bradley S, Ferguson   +1 more
openaire   +2 more sources

LKB1-Dependent Signaling Pathways

Annual Review of Biochemistry, 2006
This review focuses on remarkable recent findings concerning the mechanism by which the LKB1 protein kinase that is mutated in Peutz-Jeghers cancer syndrome operates as a tumor suppressor. We discuss evidence that the cellular localization and activity of LKB1 is controlled through its interaction with a catalytically inactive protein resembling a ...
Dario R, Alessi, Kei, Sakamoto, Jose R, Bayascas   +2 more
openaire   +2 more sources

Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance.

Seminars in Cancer Biology, 2019
Ovarian cancer (OC) is a lethal gynecological cancer. The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling pathway plays an important role in the regulation of cell survival, growth, and proliferation ...
M. Ediriweera, K. Tennekoon, S. Samarakoon   +2 more
semanticscholar   +1 more source