Results 221 to 230 of about 3,298,558 (257)

Signaling pathways of inflammation in CIA model of rheumatoid arthritis regulated by cannabichromene. [PDF]

J Cannabis Res
Sklenárová M, Šteigerová M, Jelínek P, Bazyuk M, Merdita S, Chaban B, Hlaváč J, Stránský D, Fučíková M, Šoóš M, Šíma M, Slanař O.   +11 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Molecular and Cellular Signaling Pathways of the Effects of Hypoxia and Hypercapnia on the Mechanisms of Neuroinflammation. [PDF]

Int J Mol Sci
Chekulaev PA, Zembatov GM, Namiot ED, Alekseeva TM, Ternovykh IK, Manasova ZS, Kulikov VP, Andriutsa NS, Tregub PP.   +8 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Annexin A1 as a Key Modulator of Inflammatory, Glial, and Angiogenic Signaling Pathways in Diabetic Retinopathy. [PDF]

Invest Ophthalmol Vis Sci
da Silva RA, Ferreira LPS, Roda VMP, Dos Santos DD, Faria CS, Dalmaso B, da Silva GS, Del Debbio CB, Bastos DR, Sandri S, Farsky SHP, Regatieri CVS, Gil CD.   +12 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Transcriptomic Association Between Poliovirus Receptor (PVR/CD155) and Claudin Signaling Pathways in Colorectal Cancer. [PDF]

Cancer Diagn Progn
Lehrer S, Rheinstein PH.
europepmc   +1 more source

Oncogenic signaling pathways in ameloblastoma and their implications for precision based therapy. [PDF]

Discov Oncol
Boukssim S, Soualem H, Benjelloun L.
europepmc   +1 more source