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IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
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Emerging agents that target signaling pathways in cancer fibroblast cells (Review). [PDF]
Wan Y, Liu XQ, Liu D, Li KD, Zhang DD.
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The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
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Mechanisms of T cell activation: Integrating signaling pathways, experimental models, and therapeutic implications. [PDF]
Hakami MA +5 more
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Lipid Metabolic Reprogramming in Periodontitis-Associated Alveolar Bone Remodeling: Mechanisms, Signaling Pathways, and Therapeutic Implications. [PDF]
Wang J +8 more
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Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review). [PDF]
Yang X +7 more
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Cordycepin Alleviates Acute Lung Injury by Targeting TAK1 to Inhibit MAPK and NF-κB Signaling Pathways. [PDF]
Wang J +10 more
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Signaling Pathways in Bone Development and Their Related Skeletal Dysplasia
International Journal of Molecular Sciences, 2021Valérie Cormier-Daire
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