Results 321 to 330 of about 2,211,530 (330)
Some of the next articles are maybe not open access.
Osteoclast signalling pathways
Biochemical and Biophysical Research Communications, 2005The osteoclast is a monocyte-derived cell with complex regulatory control due to its role, balancing calcium homeostasis with skeletal modelling and repair. Normal differentiation requires tyrosine kinase- and tumor necrosis-family receptors, normally fms and RANK.
Lisa J. Robinson +2 more
openaire +3 more sources
Science's STKE, 2006
Notch is a receptor that mediates intercellular signaling through a pathway conserved across the metazoa. It is involved in cell fate assignation and pattern formation during development. The receptor acts as a membrane-tethered transcription factor and is activated by members of the Delta, Serrate, Lag-2 family of Notch ligands, which trigger two ...
Matthias T. Ehebauer +2 more
openaire +3 more sources
Notch is a receptor that mediates intercellular signaling through a pathway conserved across the metazoa. It is involved in cell fate assignation and pattern formation during development. The receptor acts as a membrane-tethered transcription factor and is activated by members of the Delta, Serrate, Lag-2 family of Notch ligands, which trigger two ...
Matthias T. Ehebauer +2 more
openaire +3 more sources
Gibberellin signalling pathway
Current Opinion in Plant Biology, 2003Recent molecular biological and genetical studies have identified several positive and negative regulators of gibberellin (GA) signalling pathways in higher plants. The DELLA protein functions as a negative regulator of GA signalling; its degradation through the ubiquitin/proteasome pathway is a key event in the regulation of GA-stimulated processes.
Kenji Gomi, Makoto Matsuoka
openaire +2 more sources
Basophil Stimulation and Signaling Pathways [PDF]
, 2014 Despite the growing use of flow cytometry to analyze the functional characteristics of basophils, the intracellular signaling cascades that control their ability to elaborate various pro-allergic and inflammatory mediators and cytokines remain comparatively obscure.
Knol, E, Gibbs, B.F.
openaire +4 more sources
Science's STKE, 2007
Cytokinins are key regulators of a large number of processes in plant development, which is highly plastic and adaptive, and remarkably resilient and self-perpetuating. Cytokinin signaling involves a multistep two-component system, also called a phosphorelay signaling system.
Jen Sheen, Bruno Müller
openaire +3 more sources
Cytokinins are key regulators of a large number of processes in plant development, which is highly plastic and adaptive, and remarkably resilient and self-perpetuating. Cytokinin signaling involves a multistep two-component system, also called a phosphorelay signaling system.
Jen Sheen, Bruno Müller
openaire +3 more sources
Angiogenic Signalling Pathways
2008Hypoxia is widely recognised as a key driving force for tumor angiogenesis by its induction of vascular endothelial growth factor (VEGF) and other direct-acting angiogenic factors. We describe the effect of hypoxia on gene expression and downstream angiogenic signalling; however, the angiogenic process is complex, and many other signalling pathways ...
Roy Bicknell, Zubair Ahmed
openaire +3 more sources
2013
Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and other pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Many of the pro-inflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK ...
openaire +1 more source
Oral, small-molecule signalling pathway inhibitors, including ones that inhibit the JAK and other pathways, are currently in development for the treatment of rheumatoid arthritis (RA). Many of the pro-inflammatory cytokines implicated in the pathogenesis of RA utilize cell signalling that involves the JAK-STAT pathways and therefore inhibition of JAK ...
openaire +1 more source
Signaling pathways in glioblastoma
Critical Reviews in Oncology/HematologyCancer is one of the main public health problems worldwide. Among tumors of the Central Nervous System (CNS), glioblastoma (GBM) affects 49.1 % of malignant brain tumors, and despite standard treatment, patients diagnosed with GBM have a dismal prognosis, a high rate of recurrence after tumor resection and poor survival.
Isabella Gomes +2 more
openaire +2 more sources