Results 61 to 70 of about 1,037,302 (309)
Nature Communications, 2017 Sequestering mRNA in cytoplasmic stress granules is a mechanism for translational repression. Here the authors find that p53 mRNA, present in stress granules in activated B lymphocytes, is released upon DNA damage and is translated in a CAP-independent ...
Manuel D. Díaz-Muñoz +5 more
doaj +1 more source
KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]
, 2009 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny +4 more
core +1 more source
Cell, 1995 Calcium ions (Ca(2+)) impact nearly every aspect of cellular life. This review examines the principles of Ca(2+) signaling, from changes in protein conformations driven by Ca(2+) to the mechanisms that control Ca(2+) levels in the cytoplasm and organelles.
openaire +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider +4 more
wiley +1 more source
Neuronal signalling of zinc: from detection and modulation to function
Open Biology, 2022 Zinc is an essential trace element that stabilizes protein structures and allosterically modulates a plethora of enzymes, ion channels and neurotransmitter receptors.
Chen Zhang +3 more
doaj +1 more source
, 2016 We use a recently discovered constrained de Finetti reduction (aka "Post-Selection Lemma") to study the parallel repetition of multi-player non-local games under no-signalling strategies.
Lancien, Cécilia, Winter, Andreas
core +3 more sources
Signals and Signal Processing for the Electrophysiologist [PDF]
Circulation: Arrhythmia and Electrophysiology, 2011 In part II of this series, using the background covered in part I on electrogram acquisition and signal processing, we discuss potential errors in mapping because of artifact or inappropriate filtering of signals that may lead to unsuitable selection of ablation sites. ### Saturation Artifact If a 3-mV peak signal is being amplified at a gain of 5000,
K L, Venkatachalam +2 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background 131I‐metaiodobenzylguanidine (131I‐MIBG) radiotherapy is a key treatment for relapsed and refractory (R/R) neuroblastoma (NB). Patients with R/R disease treated in the modern era are increasingly exposed to anti‐GD2 immunotherapy, which exerts selective pressure and may modify both tumor cell state and microenvironment.
Benjamin J. Lerman +7 more
wiley +1 more source
MicroRNA-155 is essential for the optimal proliferation and survival of plasmablast B cells
Life Science Alliance, 2019 Tracking antigen-specific B cells in vivo since the onset of antigen stimulation shows that miR-155 regulates the early expansion of B-blasts and later on the optimal proliferation and survival of plasmablasts in a B-cell–intrinsic manner.
Giuseppina Arbore +6 more
doaj +1 more source
Cells, 2020 The founder cells of the Nucleus pulposus, the centre of the intervertebral disc, originate in the embryonic notochord. After birth, mature notochordal cells (NC) are identified as key regulators of disc homeostasis. Better understanding of their biology
Pauline Colombier +10 more
doaj +1 more source