Results 51 to 60 of about 1,037,302 (309)

IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics

Nature Communications
Paracrine IL-2 signalling drives the CD8 + T cell expansion and differentiation that allow protection against viral infections, but the underlying molecular events are incompletely understood.
Diane Maurice, Patrick Costello, Jessica Diring, Francesco Gualdrini, Bruno Frederico, Richard Treisman   +5 more
doaj   +1 more source

Passenger accumulator fed railcars in regional railway traffic [PDF]

Transport Problems, 2015
This paper is focused on contemporary posibilities of replacement diesel-powered railcars by accumulator powered railcars in regional railway traffic. In the first part of the paper, there are described advantages and disadvantages of this replacement ...
Radovan DOLEČEK, Ondřej ČERNÝ, Ladislav MLYNAŘÍK, Petr SÝKORA   +3 more
doaj  

Differential regulation of the Epr3 receptor coordinates membrane-restricted rhizobial colonization of root nodule primordia

Nature Communications, 2017
TheLotus japonicus LysM receptor kinase EPR3 perceives rhizobial exopolysaccharides to initiate infection of the root epidermis. Here the authors show that EPR3 also mediates infection thread progression in the root cortex and show that key transcription
Yasuyuki Kawaharada, Mette W. Nielsen, Simon Kelly, Euan K. James, Kasper R. Andersen, Sheena R. Rasmussen, Winnie Füchtbauer, Lene H. Madsen, Anne B. Heckmann, Simona Radutoiu, Jens Stougaard   +10 more
doaj   +1 more source

Arf6 is necessary for senseless expression in response to wingless signalling during Drosophila wing development

Biology Open, 2021
Wnt signalling is a core pathway involved in a wide range of developmental processes throughout the metazoa. In vitro studies have suggested that the small GTP binding protein Arf6 regulates upstream steps of Wnt transduction, by promoting the ...
Julien Marcetteau, Tamàs Matusek, Frédéric Luton, Pascal P. Thérond   +3 more
doaj   +1 more source

Hedgehog Signalling in Androgen Independent Prostate Cancer [PDF]

, 2008
Objectives: Androgen-deprivation therapy effectively shrinks hormone-naïve prostate cancer, both in the prostate and at sites of distant metastasis.
Bisson, Isabelle, Ktori, Elena, McFaul, Siobhan, Oliver, R. Tim D, Price, Anna M., Prowse, David M., Purkis, Patricia E., Shaw, Greg   +7 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Secretion of the Phosphorylated Form of S100A9 from Neutrophils Is Essential for the Proinflammatory Functions of Extracellular S100A8/A9

Frontiers in Immunology, 2018
S100A8 and S100A9 are members of the S100 family of cytoplasmic EF-hand Ca2+-binding proteins and are abundantly expressed in the cytosol of neutrophils. In addition to their intracellular roles, S100A8/A9 can be secreted in the extracellular environment
Véronique Schenten, Sébastien Plançon, Nicolas Jung, Justine Hann, Jean-Luc Bueb, Sabrina Bréchard, Eric J. Tschirhart, Fabrice Tolle   +7 more
doaj   +1 more source

Self Replication and Signalling [PDF]

, 2007
It is known that if one could clone an arbitrary quantum state one could send signal faster than the speed of light. However it remains interesting to see that if one can perfectly self replicate an arbitrary quantum state, does it violate the no ...
A.K. Pati, A.K. Pati, A.K. Pati, B. S. Choudhury, I. Chakrabarty, I. Chattopadhyay, J. Neumann Von, M.A. Nielsen, Prashant, , W.K. Wootters   +9 more
core   +1 more source

The Fate (Outcome) of Clinically Apparent Single Lesion and Oligofocal Nephroblastomatosis Treated According to SIOP/GPOH Protocols for Wilms Tumor

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background The management of clinically apparent single lesions or oligofocal nephroblastomatosis, a facultative precursor of nephroblastoma, remains debated. Methods We retrospectively analyzed 37 patients with clinically apparent single or oligofocal nephroblastomatosis (two to three lesions per kidney) among 2347 patients registered between
Nils Welter, Jens‐Peter Schenk, Jenny Wegert, Manfred Gessler, Leo Kager, Stefan Wagenpfeil, Marina Müller, Jean‐Michel Wolff, Joerg Fuchs, Steven W. Warmann, Clemens‐Magnus Meier, Jochen Hubertus, Christian Rübe, Christian Vokuhl, Patrick Melchior, Lena Tschirner, Norbert Graf, Rhoikos Furtwängler   +17 more
wiley   +1 more source

ADP-ribosylation signalling and human disease [PDF]

Open Biology, 2019
ADP-ribosylation (ADPr) is a reversible post-translational modification of proteins, which controls major cellular and biological processes, including DNA damage repair, cell proliferation and differentiation, metabolism, stress and immune responses.
Luca Palazzo, Petra Mikolčević, Andreja Mikoč, Ivan Ahel   +3 more
doaj   +1 more source