Means of intracellular communication: touching, kissing, fusing
Eukaryotic cells are complicated factories that need ensure productivity and functionality on the cellular level as well as being able to communicate with their environment. In order to do so cells developed intracellular communication systems.
Anne Spang
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Signal transduction and signaling networks
Cellular signaling can be complex and dynamic. In the past several decades, it has become clear that many signal transduction pathways are not simple one-way transmissions of upstream stimuli, but are mediated through extremely complicated networks. Our next challenge is to move beyond the static biochemical description of networks into developing a ...
Ikeda, Fumiyo, Lahav, Galit
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Split intein-mediated selection of cells containing two plasmids using a single antibiotic
Engineering cell lines often requires multiple plasmids with different selection markers. Here the authors present SiMPl, a method based on rationally engineered split enzymes which get reconstituted via intein-mediated protein splicing to maintain two ...
Navaneethan Palanisamy +9 more
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Notch activates Wnt-4 signalling to control medio-lateral patterning of the pronephros [PDF]
Previous studies have highlighted a role for the Notch signalling pathway during pronephrogenesis in the amphibian Xenopus laevis, and in nephron development in the mammalian metanephros, yet a mechanism for this function remains elusive.
Jones, E. A., Naylor, Richard William
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Asymmetric information: Causes, consequences and the market and institutional responses [PDF]
One of the assumptions of perfect competition market model is symmetric (full) information of market participants. However, in reality, market participants are most often asymmetrically informed.
Trivić Nada
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Hedgehog (Hh) proteins constitute one family of a small number of secreted signaling proteins that together regulate multiple aspects of animal development, tissue homeostasis and regeneration. Originally uncovered through genetic analyses in Drosophila, their subsequent discovery in vertebrates has provided a paradigm for the role of morphogens in ...
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Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML). The nucleus is
Jie Xian +12 more
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Nonlocal quantum information transfer without superluminal signalling and communication
It is a frequent assumption that - via superluminal information transfers - superluminal signals capable of enabling communication are necessarily exchanged in any quantum theory that posits hidden superluminal influences.
Groessing, Gerhard, Walleczek, Jan
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Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. [PDF]
This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis
Roberts, C
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HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan +54 more
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