Results 21 to 30 of about 1,037,302 (309)

Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways

Nature Communications, 2021
The role of the transcriptional effector SMAD4 in vertebrate embryo development remains unresolved. Here the authors show that in the absence of Smad4, dorsal/ventral embryo patterning is disrupted due to the loss of BMP signaling, while Nodal signaling ...
Luca Guglielmi, Claire Heliot, Sunil Kumar, Yuriy Alexandrov, Ilaria Gori, Foteini Papaleonidopoulou, Christopher Barrington, Philip East, Andrew D. Economou, Paul M. W. French, James McGinty, Caroline S. Hill   +11 more
doaj   +1 more source

Interplay between FGFR2b-induced autophagy and phagocytosis: role of PLCγ-mediated signalling [PDF]

, 2017
Signalling of the epithelial splicing variant of the fibroblast growth factor receptor 2 (FGFR2b) induces both autophagy and phagocytosis in human keratinocytes.
Belleudi, Francesca, Nanni, Monica, Raffa, Salvatore, Ranieri, Danilo, Torrisi, Maria Rosaria   +4 more
core   +1 more source

Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]

, 2012
Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Dikic, Ivan, Fulda, Simone, Rajalingam, Krishnaraj   +2 more
core   +2 more sources

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis [PDF]

, 2018
Suppressor of Fused (SuFu), a tumour suppressor mutated in medulloblastoma, is a central player of Hh signalling, a pathway crucial for development and deregulated in cancer.
Alfonsi, Romina, Bernardi, Flavia, Bufalieri, Francesca, Canettieri, Gianluca, Capalbo, Carlo, Coni, Sonia, De Smaele, Enrico, Di Marcotullio, Lucia, Faedda, Roberta, Ferretti, Elisabetta, Guardavaccaro, Daniele, Gulino, Alberto, Infante, Paola, Kool, Marcel, Lospinoso Severini, Ludovica, Maroder, Marella, Mazzà, Daniela, Mori, Mattia, Petroni, Marialaura, Pfister, Stefan M., Po, Agnese, Screpanti, Isabella, Siler, Mariangela   +22 more
core   +5 more sources

Author Correction: Split intein-mediated selection of cells containing two plasmids using a single antibiotic

Nature Communications, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Navaneethan Palanisamy, Anna Degen, Anna Morath, Jara Ballestin Ballestin, Claudia Juraske, Mehmet Ali Öztürk, Georg A. Sprenger, Jung-Won Youn, Wolfgang W. Schamel, Barbara Di Ventura   +9 more
doaj   +1 more source

Intra-tumour signalling entropy determines clinical outcome in breast and lung cancer. [PDF]

, 2015
The cancer stem cell hypothesis, that a small population of tumour cells are responsible for tumorigenesis and cancer progression, is becoming widely accepted and recent evidence has suggested a prognostic and predictive role for such cells. Intra-tumour
Banerji, CR, Caldas, C, Severini, S, Teschendorff, AE   +3 more
core   +3 more sources

Awards as Signals [PDF]

SSRN Electronic Journal, 2010
Awards are widespread in all countries and are prevalent both in the public sphere and in the private sector. This paper argues, and empirically supports, that awards serve public functions and economists should take them seriously. Using a unique cross-country data set, we suggest that awards serve as signals.
Frey, Bruno S, Neckermann, Susanne
openaire   +5 more sources

Retrograde semaphorin-plexin signalling drives homeostatic synaptic plasticity. [PDF]

, 2017
Homeostatic signalling systems ensure stable but flexible neural activity and animal behaviour. Presynaptic homeostatic plasticity is a conserved form of neuronal homeostatic signalling that is observed in organisms ranging from Drosophila to human ...
A Mahr, A Sahay, AL Franciscovich, AL Kolodkin, Brian O. Orr, CA Frank, CA Frank, DS Syed, E Koropouli, E Marder, F Bouzioukh, G Turrigiano, Graeme W. Davis, GW Davis, HJ Bellen, J de Wit, JC Ayoob, JR Terman, KJT Venken, M Müller, MA Gaviño, MA Younger, MB Ramocki, N Harris, N Uesaka, R-J Hung, R-J Hung, RA Carrillo, Richard D. Fetter, RJ Hung, S Meltzer, SA Petersen, SG Cull-Candy, T Wang, T Wang, TS Tran, Y Luo, Z Wu   +37 more
core   +1 more source

Mobility Prediction for Handover Management in Cellular Networks with Control/Data Separation [PDF]

, 2015
In research community, a new radio access network architecture with a logical separation between control plane (CP) and data plane (DP) has been proposed for future cellular systems.
Hoseinitabatabaei, Seyed Amir, Imran, Ali, Imran, Muhammad, Mohamed, Abdelrahim, Onireti, Oluwakayode, Tafazolli, Rahim   +5 more
core   +1 more source

A simple optogenetic MAPK inhibitor design reveals resonance between transcription-regulating circuitry and temporally-encoded inputs

Nature Communications, 2017
Light-sensitive regulators of protein kinases could offer valuable insights into intracellular signalling. Here the authors design an optogenetic inhibitor of c-Jun N-terminal kinase (JNK) and show evidence for resonance in JNK signalling circuits in ...
Raquel M. Melero-Fernandez de Mera, Li-Li Li, Arkadiusz Popinigis, Katryna Cisek, Minna Tuittila, Leena Yadav, Andrius Serva, Michael J. Courtney   +7 more
doaj   +1 more source