Results 1 to 10 of about 1,037,153 (160)
Frontiers in Immunology, 2022 Host defense against bacterial and fungal infections diminishes with age. In humans, impaired neutrophil responses are thought to contribute to this decline. However, it remains unclear whether neutrophil responses are also impaired in old mice. Here, we
Kirsti Hornigold +10 more
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Scientific Reports, 2023 Norbin is an adaptor protein that binds numerous G protein-coupled receptors (GPCRs), is highly expressed in neurons, and is essential for a functioning nervous system in rodent models. Yet, beyond its control of neurite outgrowth and synaptic plasticity,
Valdemar B. I. Johansen +10 more
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The Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
Frontiers in Immunology, 2023 Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav, and Dock ...
Kirsti Hornigold +17 more
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Stem Cells International, 2023 Mesenchymal stromal cells (MSCs) administered intravenously (IV) have shown efficacy in preclinical models of various diseases. This is despite the cells not reaching the site of injury due to entrapment in the lungs.
Alejandra Hernandez Pichardo +3 more
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Development and characterization of a monoclonal antibody blocking human TRPM4 channel
Scientific Reports, 2021 TRPM4 is a calcium-activated non-selective monovalent cation channel implicated in diseases such as stroke. Lack of potent and selective inhibitors remains a major challenge for studying TRPM4.
See Wee Low +5 more
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TRAIN HEADWAY OPTIMISATION USING VIRTUAL BLOCKS [PDF]
Scientific Journal of Silesian University of Technology. Series Transport, 2021 Although the implementation of a new Automatic Train Protection (ATP) system increases the safety level, it also exerts some impact on the blocking time in block sections, and consequently, on the headway between trains.
Maciej IRLIK
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The RNA-binding proteins Zfp36l1 and Zfp36l2 act redundantly in myogenesis
Skeletal Muscle, 2018 Background Members of the ZFP36 family of RNA-binding proteins regulate gene expression post-transcriptionally by binding to AU-rich elements in the 3’UTR of mRNA and stimulating mRNA degradation.
Hema Bye-A-Jee +6 more
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The basic chemistry of exercise-induced DNA oxidation:oxidative damage, redox signalling and their interplay [PDF]
, 2015 Acute exercise increases reactive oxygen and nitrogen species generation. This phenomenon is associated with two major outcomes: (1) redox signalling and (2) macromolecule damage.
Close, Graeme L. +5 more
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The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
Nature Communications, 2023 RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation and ...
Xiangyi S. Wang +6 more
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A methodological approach to BISDN signalling performance [PDF]
, 1994 Sophisticated signalling protocols are required to properly handle the complex multimedia, multiparty services supported by the forthcoming BISDN. The implementation feasibility of these protocols should be evaluated during their design phase, so that ...
Hou, X. +4 more
core +2 more sources