Results 91 to 100 of about 968,312 (333)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Ocean Wave Period Measurements Using S-Band Signals of Opportunity Reflections
IEEE Journal of Selected Topics in Applied Earth Observations and Remote SensingOcean wave periods are estimated using measurements of S-band signals-of-opportunity reflections from the sea surface. The measurements were collected on an oil platform and show a time evolving Doppler centroid frequency and spectral width due to the ...
James Gaudreau +5 more
doaj +1 more source
Early opportunity signals of a tipping point in the UK's second-hand electric vehicle market [PDF]
Earth System DynamicsThe use of early warning signals to detect the movement of natural systems towards tipping points is well established. Here, we explore whether the same indicators can provide early opportunity signals (EOSs) of a tipping point in a social dataset: views
C. A. Boulton +2 more
doaj +1 more source
ENDOGENOUS NOISE TRADERS [PDF]
We construct a parsimonious model of a financial market where the marginal investor is an endogenous noise trader. Such a trader anticipates that future shocks may force him to exit his position. In compensation he requires a higher return.
Salomonsson, Marcus
core
Epithelial–Mesenchymal Transition Signaling and Prostate Cancer Stem Cells: Emerging Biomarkers and Opportunities for Precision Therapeutics [PDF]
, 2021 Luiz Paulo Chaves +4 more
openalex +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Dianxin kexue, 2023 Communication and navigation symbiosis refers to the coexistence of these signals in the satellite ecological environment.For single-function low-orbit satellite constellations for positioning or communication, it is difficult to quickly perform ...
Jie SHEN +6 more
doaj +2 more sources
Oncogenic Signalling of Growth Factor Receptors in Cancer: Mechanisms and Therapeutic Opportunities [PDF]
, 2022 Anica Dricu
openalex +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source