Results 41 to 50 of about 624,213 (299)

Development and validation of a novel anoikis-related gene signature in clear cell renal cell carcinoma

open access: yesFrontiers in Oncology, 2023
BackgroundDespite numerous treatments available, clear cell renal cell carcinoma (ccRCC) remains a deadly and invasive cancer. Anoikis-related genes (ARGs) are essential regulators of tumor metastasis and development. However, the potential roles of ARGs
Qihang Wu   +6 more
doaj   +1 more source

Cerebrospinal Fluid Liquid Biopsy Enables Targeted Therapy Without Tissue Diagnosis in Pediatric Low‐Grade Gliomas With BRAF V600E Mutation

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT We present two pediatric cases of pediatric low‐grade gliomas (PLGG) with BRAF V600E mutations diagnosed and monitored using cerebrospinal fluid (CSF) liquid biopsy analyzed via digital droplet PCR (ddPCR), without tissue biopsy. Both patients were treated with dabrafenib and trametinib and monitored through clinical assessments, magnetic ...
Hannah Sultan   +5 more
wiley   +1 more source

Identification of the State of Electrical Appliances with the Use of a Pulse Signal Generator

open access: yesEnergies, 2021
The paper presents the novel HF-GEN method for determining the characteristics of Electrical Appliance (EA) operating in the end-user environment. The method includes a measurement system that uses a pulse signal generator to improve the quality of EA ...
Augustyn Wójcik   +4 more
doaj   +1 more source

Changes in Body Composition in Children and Young People Undergoing Treatment for Acute Lymphoblastic Leukemia: A Systematic Review and Meta‐Analysis

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Ongoing evidence indicates increased risk of sarcopenic obesity among children and young people (CYP) with acute lymphoblastic leukemia (ALL), often beginning early in treatment, persisting into survivorship. This review evaluates current literature on body composition in CYP with ALL during and after treatment.
Lina A. Zahed   +5 more
wiley   +1 more source

Expression Signature

open access: yes, 2013
he prostate gland can be the site of multiple neoplastic transformation events, many of which give rise only to latent prostate cancer that does not progress to clinically detectable disease. While evidence of major subtypes of prostate cancer is lacking at the histopathological level, recent genomic analyses have provided increasing evidence for ...
STAIBANO, STEFANIA, Celetti, Angela
openaire   +4 more sources

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura   +5 more
wiley   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser   +6 more
wiley   +1 more source

Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms

open access: yesCell Reports, 2016
Alternative splicing (AS) is an important source of proteome diversity in eukaryotes. However, how this affects protein repertoires at a single-cell level remains an open question.
Karen Yap   +4 more
doaj   +1 more source

Identification of Novel Prognostic Risk Signatures of Soft Tissue Sarcoma Based on Ferroptosis-Related Genes

open access: yesFrontiers in Oncology, 2021
BackgroundThe role of ferroptosis in tumorigenesis has been confirmed in previous studies. However, the comprehensive analysis of ferroptosis-related gene (FRG) to study the role of FRG in soft tissue sarcoma (STS) is lacking.MethodsRNA sequencing ...
Wenjing Huang   +6 more
doaj   +1 more source

Graded Signatures

open access: yes, 2015
Motivated by the application of anonymous petitions, we formalize a new primitive called "graded signatures", which enables a user to consolidate a set of signatures on a message m originating from l different signers that are members of a PKI. We call the value $$l \in \mathbb {N}$$l∈N, the grade of the consolidated signature.
Kiayias, A., Osmanoglu, M., Tang, Q.
openaire   +2 more sources

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