Results 61 to 70 of about 32,664 (283)

Identification of common and divergent gene expression signatures in patients with venous and arterial thrombosis using data from public repositories.

PLoS ONE, 2020
STRENGTHS AND LIMITATIONS OF THIS STUDY:Our results represent the first comparison of venous and arterial thrombosis at the transcriptomic level.Our main result was the demonstration that immunothrombosis pathways are important to the pathophysiology of ...
Bidossessi Wilfried Hounkpe, Rafaela de Oliveira Benatti, Benilton de Sá Carvalho, Erich Vinicius De Paula   +3 more
doaj   +1 more source

Alzheimer’s disease: insights from a network medicine perspective

Scientific Reports, 2022
Alzheimer’s disease (AD) is the most common neurodegenerative disease that currently lacks available effective therapy. Thus, identifying novel molecular biomarkers for diagnosis and treatment of AD is urgently demanded. In this study, we exploited tools
Federica Conte, Paola Paci
doaj   +1 more source

Non-metricity signatures on the Higgs boson signal strengths at the LHC

Journal of High Energy Physics, 2022
Abstract In this work we study the high-energy Higgs boson phenomenology associated to the non-metricity scale ΛQ at the LHC. Non-metricity is present in more generic non-Riemannian geometries describing gravity beyond General Relativity and exhibits nice features in astronomy and cosmology, and it can be analysed perturbatively ...
openaire   +5 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Airgap and stray magnetic flux monitoring techniques for fault diagnosis of electrical machines: An overview

IET Electric Power Applications, 2022
Flux‐based fault diagnosis methods have attracted ever‐increasing attention from technical communities because of their potential diagnostic capabilities and ability to overcome weaknesses of the traditional methods such as motor current signature ...
Ehsan Mazaheri‐Tehrani, Jawad Faiz
doaj   +1 more source

Dynamic stress–strength reliability estimation of system with survival signature

Statistical Theory and Related Fields, 2018
In this paper, we proposed a dynamic stress–strength model for coherent system. It is supposed that the system consists of n components with initial random strength and each component is subjected to random stresses. The stresses, applied repeatedly at random cycle times, will cause the degradation of strength.
Yiming Liu, Yimin Shi, Xuchao Bai, Bin Liu   +3 more
openaire   +2 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source