Results 191 to 200 of about 167,728,565 (254)

Candidate Genes, Markers, Signatures of Selection, and Quantitative Trait Loci (QTLs) and Their Association with Economic Traits in Livestock: Genomic Insights and Selection. [PDF]

Int J Mol Sci
Hassanine NNAM, Saleh AA, Essa MOA, Adam SY, Mohai Ud Din R, Rehman SU, Ali R, Husien HM, Wang M.   +8 more
europepmc   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Uncovering genomic diversity and signatures of selection in red Angus × Chinese red steppe crossbred cattle population. [PDF]

Sci Rep
Rostamzadeh Mahdabi E, Tian R, Tian J, Asadollahpour Nanaie H, Wang X, Zhao M, Li H, Dalai B, Sai Y, Guo W, Li Y, Zhang H, Esmailizadeh A.   +12 more
europepmc   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Genetic diversity and signatures of selection in Icelandic horses and Exmoor ponies. [PDF]

BMC Genomics
Sigurðardóttir H, Ablondi M, Kristjansson T, Lindgren G, Eriksson S.   +4 more
europepmc   +1 more source

Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi, Katharine Lee, Kerry C. Nix, Miguel Menchaca, Xiwei Shé, Lorelei Santa Maria, Wei Wu, Zihuai He, Fiona M. Baumer   +8 more
wiley   +1 more source

Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs. [PDF]

Imeta
Liu L, Yi G, Yao Y, Liu Y, Li J, Yang Y, Liu M, Fang L, Mo D, Zhang L, Liu Y, Niu Y, Wang L, Qu X, Pan Z, Wang L, Chen M, Fan X, Chen Y, Zhang Y, Li X, Wang Z, Tang Y, Huang H, Yuan P, Liao Y, Li X, Yin Z, Liu D, Zhang D, Zhou Q, Wu W, Jiang J, Gao Y, Liu GE, Wang L, Chen Y, Li K, Groenen MAM, Tang Z.   +39 more
europepmc   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

Genomic and Behavioral Signatures of Selection for Ethanol Preference from the Heterogeneous Stock Collaborative Cross Mice - The Central Nucleus of the Amygdala. [PDF]

Addict Neurosci
Anderson JQ, Darakjian P, Hitzemann R, Cervera-Juanes R, Zimmerman KD, Reed C, Lockwood D, Ozburn AR, Phillips TJ.   +8 more
europepmc   +1 more source