Results 221 to 230 of about 546,808 (280)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Genetic diversity and signatures of selection in Icelandic horses and Exmoor ponies. [PDF]

BMC Genomics
Sigurðardóttir H, Ablondi M, Kristjansson T, Lindgren G, Eriksson S.   +4 more
europepmc   +1 more source

Genomic Diversity Profiling and Breed-Specific Evolutionary Signatures of Selection in Arunachali Yak. [PDF]

Genes (Basel), 2022
Kour A, Niranjan SK, Malayaperumal M, Surati U, Pukhrambam M, Sivalingam J, Kumar A, Sarkar M.   +7 more
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Signatures of Selection on Mitonuclear Integrated Genes Uncover Hidden Mitogenomic Variation in Fur Seals. [PDF]

Genome Biol Evol, 2022
Vendrami DLJ, Gossmann TI, Chakarov N, Paijmans AJ, Litzke V, Eyre-Walker A, Forcada J, Hoffman JI.   +7 more
europepmc   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Genome-wide scans for signatures of selection in North African sheep reveals differentially selected regions between fat- and thin-tailed breeds. [PDF]

Anim Genet
Ben-Jemaa S, Yahyaoui G, Kdidi S, Najjari A, Lenstra JA, Mastrangelo S, Gaouar SBS, Mwacharo JM, Khorchani T, Yahyaoui MH.   +9 more
europepmc   +1 more source

Genomics reveal population structure, evolutionary history, and signatures of selection in the northern bottlenose whale, Hyperoodon ampullatus. [PDF]

Mol Ecol, 2022
de Greef E, Einfeldt AL, Miller PJO, Ferguson SH, Garroway CJ, Lefort KJ, Paterson IG, Bentzen P, Feyrer LJ.   +8 more
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

Correction: Comparing Patterns of Natural Selection across Species Using Selective Signatures

PLoS Genetics, 2008
B. Jesse Shapiro, Eric J Alm
openaire   +2 more sources