Results 111 to 120 of about 59,140 (257)

Sildenafil Can Affect Innate and Adaptive Immune System in Both Experimental Animals and Patients

Journal of Immunological Research, 2017
Sildenafil, a type 5 phosphodiesterase inhibitor (PDE5-I), is primarily used for treating erectile dysfunction. Sildenafil inhibits the degradation of cyclic guanosine monophosphate (cGMP) by competing with cGMP for binding site of PDE5.
M. Kniotek, Agnieszka Boguska
semanticscholar   +1 more source

Population Pharmacokinetics of Sildenafil in Dogs With Naturally Occurring Pulmonary Hypertension

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics of sildenafil are ill‐defined in dogs with naturally occurring pulmonary hypertension (PH). Because the plasma concentrations of sildenafil have not been reported for dogs with this disease, this study aimed to describe the population pharmacokinetics of sildenafil in a sample of dogs with PH. Twenty client‐owned dogs with
Mariko Yata, Teresa C. DeFrancesco, John D. Bonagura, Mark G. Papich   +3 more
wiley   +1 more source

The issue of recreational use of sildenafil

Journal of Education, Health and Sport
Introduction and purpose Erectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse.
Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Weronika Chachaj, Paulina Słomka, Edyta Gwóźdź, Dawid Konieczko, Ewa Gardocka   +9 more
doaj   +1 more source

Aberrant migration and surgical removal of a heartworm (Dirofilaria immitis) from the femoral artery of a cat. [PDF]

, 2018
A cat was evaluated for an acute-onset of right pelvic limb paresis. Thoracic radiographs revealed normal cardiac size and tortuous pulmonary arteries.
Balsa, Ingrid M, Gunther-Harrington, Catherine T, Honkavaara, Juhana, McLarty, Ehren M, Oldach, Maureen S, Phillips, Kathryn L, Stern, Joshua A, Visser, Lance C, Wakeman, Kyle A   +8 more
core   +1 more source

Rethinking Reproductive Governance: What Can Public Administration on the Island of Ireland Learn From Abortion Accompaniment?

Public Administration, EarlyView.
ABSTRACT The recent decriminalization of abortion marked a crucial step toward improved reproductive care on the island of Ireland. However, this has not translated into fully accessible abortion provision—barriers, including inaccessible services, persist, leaving gaps that public administration has not formally addressed. In response, informal actors,
Anna Theresa Schmid
wiley   +1 more source

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

Journal of Toxicology, 2014
Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity.
Mohamed A. Morsy, Salwa A. Ibrahim, Entesar F. Amin, Maha Y. Kamel, Rehab A. Rifaai, Magdy K. Hassan   +5 more
doaj   +1 more source

Effects and mechanisms of action of sildenafil citrate in human chorionic arteries

Reproductive Biology and Endocrinology, 2009
Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg, O'Toole Daniel, Maharaj Chrisen H, Carney John, Jarman James, Higgins Brendan D, Morrison John J, Laffey John G   +7 more
doaj   +1 more source

Methods of Assessment and Clinical Relevance of QT Dynamics [PDF]

, 2005
The dependence on heart rate of the QT interval has been investigated for many years and several mathematical formulae have been proposed to describe the QT interval/heart rate (or QT interval/RR interval) relationship. While the most popular is Bazett’s
Agata, Musialik-Lydka, Anna, Sliwinska, Beata, Sredniawa, Piotr, Jarski, Zbigniew, Kalarus   +4 more
core  

Safety and efficacy of blood exchange transfusion for priapism complicating sickle cell disease. [PDF]

, 2016
BACKGROUND: Priapism is unwanted painful penile erection that affects about 36% of boys and men with sickle cell disease (SCD) most of whom have sickle cell anemia. Clinically, priapism could be stuttering, minor, or major.
Adeyoju, Ayache, Ballas, Ballas, Baron, Betke, Charache, Eckman, Emond, Harms, Janes, Mantadakis, Okpala, Powars, Rackoff, Rogers, Seeler, Serjeant, Serjeant, Sharpsteen, Siegel, Talacki, Teixeira, US Department of Health and Human Services   +23 more
core   +2 more sources

Effects of pioglitazone on erectile dysfunction in sildenafil poor-responders: a randomized, controlled study

Journal of Pharmacy & Pharmaceutical Sciences, 2008
Purpose.To assess the effects of pioglitazone on sildenafil responsiveness in men with erectile dysfunction (ED) and a history of poor response to sildenafil. Methods. In a double -blinded study, 38 men aged 47 ± 1.5 years with moderate-to-severe ED and
Babak Gholamine, Manijeh Motevallian, Massoumeh Shafiei, Massoud Mahmoudian   +3 more
doaj   +1 more source