Results 81 to 90 of about 28,609 (228)

Sildenafil in the treatment of pulmonary hypertension

, 2006
Christopher F Barnett1,2, Roberto F Machado1,21Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA; 2Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health ...
Christopher F Barnett, Roberto F Machado
core  

Quantitative analysis of Sildenafil Citrat in the tablet (Viagra) by high-performance liquid chromatography (HPLC) method : Graduate Thesis for Pharmacist, Majors of Medicine Administration and Supply

, 2020
72 p.In this study, a High-performance Liquid Chromatography – Ultra vision (HPLC-UV) with PDA detector was developed to analyze genuine Viagra tablets as Samples and the sencondary reference substance for Sildenafil citrat as Standard to obtain a shape ...
Phan, Doan Thuy Tien
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Temporal Trends in Intracavernosal Injection Therapy and Penile Prosthesis Implantation in the Era of Phosphodiesterase‐5 Inhibitors for Erectile Dysfunction in Australia

ANZ Journal of Surgery, EarlyView.
ABSTRACT Introduction Phosphodiesterase‐5 inhibitors (PDE5‐Is) transformed erectile dysfunction (ED) management as first‐line therapy; nonetheless, many patients require second‐ and third‐line options due to inadequate response, side effects, or contraindications.
Nicholas Gillman, Eric Chung
wiley   +1 more source

Sildenafil provokes headache but not migraine in men with migraine without aura: a randomized, placebo-controlled crossover trial

The Journal of Headache and Pain
Background Cyclic guanosine monophosphate (cGMP)-mediated mechanisms plays a role in migraine pathophysiology. Sildenafil, a phosphodiesterase type 5 inhibitor, increases intracellular cGMP and can reliably induce migraine attacks in women.
Anas Mohammad, Ditte Bork Iversen, Nete Lundager Klokker Rausgaard, Christina Kruuse, Dagmar Beier, Tore Bjerregaard Stage, Lanfranco Pellesi   +6 more
doaj   +1 more source

Use of sildenafil citrate in cases of intrauterine growth restriction (IUGR); a prospective trial

Taiwanese Journal of Obstetrics & Gynecology, 2018
Objective: Intrauterine growth restriction (IUGR) is one of the most serious complications of pregnancy. Up to date, there is no evidence of achieving antenatal treatment of IUGR with abnormal placentation.
Mohammed Maged, Alaa Wageh, Maher Shams, Abdlgawad Elmetwally   +3 more
doaj   +1 more source

Update on the clinical utility of sildenafil in the treatment of pulmonary arterial hypertension

, 2010
Gautam V Ramani, Myung H ParkUniversity of Maryland, Baltimore, MD, USAAbstract: Sildenafil is an orally administered phosphodiesterase type 5 inhibitor that is approved for the treatment of pulmonary arterial hypertension (PAH).
Gautam V Ramani, Myung H Park
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Akt-1 phosphorylation after sildenafil treatment.

, 2013
Insulin plus sildenafil treatment (1 µM/72 h) enhances Akt-1 phosphorylation in insulin resistance condition respect to the same conditions without sildenafil. Full bars represent conditions without sildenafil, dashed bars represent sildenafil treatment.
Marco F. Lombardo (356740), Manfredi Tesauro (356745), Massimo Federici (287295), Paolo Sbraccia (356751), Lucia Gatta (356747), Massimo Fini (356749), Alfonso Bellia (356755), Francesca Ferrelli (356741), Giuseppe M. Rosano (356757), Massimiliano Caprio (356742), Claudia Consoli (356743), Giulia Donadel (356753), Donatella Pastore (356739), Andrea Fabbri (356760), Davide Lauro (251355), Caterina Mammi (356738)   +15 more
core   +1 more source

Sildenafil in IPF

, 2022
A systematic review and meta- analysis of sildenafil versus placebo or antifibrotic therapy (pirfenidone or nintedanib) in IPF ...
Tyler Pitre
core   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source