Results 81 to 90 of about 59,140 (257)

Current practices in the use of sildenafil for pulmonary arterial hypertension in Brazilian hospitals

BMC Research Notes, 2009
Background Sildenafil is a cyclic guanosine monophosphate-specific phosphodiesterase-5 inhibitor used for treating pulmonary hypertension. Although the use of sildenafil in patients under 18 years old is off-label, this inhibitor has been widely ...
Cabral Lucio M, de Souza Ana HA, Huf Gisele   +2 more
doaj   +1 more source

Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate

Drug Delivery, 2017
Vaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization.
H. Refai, Doaa H. Hassan, Rehab Abdelmonem   +2 more
semanticscholar   +1 more source

Cadmium-induced adrenal cortical autophagy in rats: possible modulation by sildenafil

Folia Morphologica, 2020
BACKGROUND: The link between autophagy, inflammatory bowel disease, ischaemic injury and cancer had been established. Reasonable evidence is available for cadmium to be related to certain cancers.
R. A. Imam, A. G. Motawei, W. A. Abd Algaleel   +2 more
doaj   +1 more source

Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis

International Urology and Nephrology, 2017
AimsErectile dysfunction (ED) is a major care problem worldwide. Tadalafil and sildenafil are the two most common phosphodiesterase 5 inhibitors used to treat ED.
Bin-Bin Gong, Ming Ma, Wenjie Xie, Xiaorong Yang, Yongming Huang, T. Sun, Yanping Luo, Jiao Huang   +7 more
semanticscholar   +1 more source

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]

, 2014
STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari, Alasmari, Baker, Barratt, Baxendale, Bjorndahl, Christopher L.R. Barratt, Comhaire, Conti, Cooper, David, Fisch, Ford, Francis, Glenn, Harrison, HFEA, Horvath, Houslay, Huacuja, Hull, Hunnicutt, Irvine, Ivic, Lefièvre, Lefièvre, Lefièvre, Linda Lefièvre, Lorna Frame, Martin, Mortimer, Mrsny, Nassar, Negri, O'Connell, Oladipo A. Madamidola, Paul G. Wyatt, Publicover, Richter, Sarah J. Martins Da Silva, Sean G. Brown, Sousa, Steve Tardif, Stone, Tesarik, Tomlinson, Tomlinson, Torres-Flores, Tournaye, Tournaye, Van der Steeg, Wang, Yang, Yovich, Yovich   +54 more
core   +5 more sources

Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure [PDF]

, 2015
Background: Pulmonary hypertension is associated with poor outcome in patients with chronic heart failure (CHF) and may be a therapeutic target. Our aims were to develop a noninvasive model for studying pulmonary vasoreactivity in CHF and characterize ...
Ciobanu, Andrea, Clark, Andrew L., Cleland, John G. F., Cleland, John G.F., Damy, Thibaud, Dubois-Rande, Jean-Luc, Dubois-Randé, Jean Luc, Guellich, Aziz, Hittinger, Luc, Hobkirk, James, Kallvikbacka-Bennett, Anna, Rigby, Alan S., Walters, Mandy   +12 more
core   +2 more sources

Hypotensive Episodes Precede Cognitive Fluctuations in Parkinson's Disease Dementia

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Cognitive fluctuations (CFs) are a disabling feature in Parkinson's disease dementia (PDD) and contribute to caregiver burden. The relationship between CFs and neurogenic orthostatic hypotension (nOH), a common autonomic complication in PDD, has not been adequately examined.
Jorge Patino, Kevin Duque, Jesus Abanto, Aaron Bloemer, Heba Deraz, Alberto J. Espay, Abhimanyu Mahajan   +6 more
wiley   +1 more source

Sildenafil amplifies calcium influx and insulin secretion in pancreatic β cells

Physiological Reports
Sildenafil, a phosphodiesterase‐5 (PDE5) inhibitor, has been shown to improve insulin sensitivity in animal models and prediabetic patients. However, its other metabolic effects remain poorly investigated.
Naoya Murao, Risa Morikawa, Yusuke Seino, Kenju Shimomura, Yuko Maejima, Yuichiro Yamada, Atsushi Suzuki   +6 more
doaj   +1 more source

Sildenafil restores cognitive function without affecting β-amyloid burden in a mouse model of Alzheimer's disease [PDF]

, 2011
BACKGROUND AND PURPOSE: Inhibitors of phosphodiesterase 5 (PDE5) affect signalling pathways by elevating cGMP, which is a second messenger involved in processes of neuroplasticity.
Aguirre, N. (Norberto), Cuadrado-Tejedor, M. (Mar), Franco, R. (Rafael), Garcia-Barroso, C. (C.), Garcia-Osta, A. (Ana), Hervias, I. (Isabel), Perez-Roldan, J.M. (J.M.), Puerta, E. (Elena), Ricobaraza, A. (Ana)   +8 more
core   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source