Results 71 to 80 of about 35,832 (220)

Sildenafil amplifies calcium influx and insulin secretion in pancreatic β cells

Physiological Reports
Sildenafil, a phosphodiesterase‐5 (PDE5) inhibitor, has been shown to improve insulin sensitivity in animal models and prediabetic patients. However, its other metabolic effects remain poorly investigated.
Naoya Murao, Risa Morikawa, Yusuke Seino, Kenju Shimomura, Yuko Maejima, Yuichiro Yamada, Atsushi Suzuki   +6 more
doaj   +1 more source

Preoperative subcutaneous sildenafil injection increases random flap survival in rats [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To investigate the effect of subcutaneous sildenafil on random flap survival. Methods: Fourteen Wistar rats, which were divided in to two groups, were used for this experimental study.
Merdan Serin, Dincer Altinel, Cem Leblebici, Burcu Biltekin, Mert Celikten, Fatih Irmak, Sevgi Kurt Yazar   +6 more
doaj   +2 more sources

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter, I. M. Adcock, C. Benito‐Villalvilla, R. Bianchini, L. Bjermer, G. Caramori, L. Cari, K. F. Chung, Z. Diamant, I. Eguiluz‐Gracia, E. F. Knol, M. Jesenak, F. Levi‐Schaffer, G. Nocentini, L. O'Mahony, O. Palomares, F. Redegeld, M. Sokolowska, B. Van Esch, M. Zurlo, C. Stellato   +20 more
wiley   +1 more source

Artificial Intelligence in Patient Education: ChatGPT for Penile Prosthesis Surgery Counseling, a Likert Scale Analysis

Andrology, EarlyView.
Abstract Introduction Erectile dysfunction (ED) significantly impacts quality of life. For patients unresponsive to conservative treatments, penile prosthesis implantation represents an effective solution with high satisfaction rates. However, the complexity and sensitive nature of the procedure often generate multiple patient concerns.
Gabriele Tulone, Nicola Pavan, Rosa Giaimo, Alchiede Franco Simonato, Alfonzo Salzano, Davide Cosentino, Francesco Claps, Alchiede Simonato   +7 more
wiley   +1 more source

Cadmium-induced adrenal cortical autophagy in rats: possible modulation by sildenafil

Folia Morphologica, 2020
BACKGROUND: The link between autophagy, inflammatory bowel disease, ischaemic injury and cancer had been established. Reasonable evidence is available for cadmium to be related to certain cancers.
R. A. Imam, A. G. Motawei, W. A. Abd Algaleel   +2 more
doaj   +1 more source

Comparison of the clinical efficacy and safety of the on‐demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation: A randomised placebo‐controlled clinical trial

Andrologia, 2018
The aim of the study was to compare the clinical efficacy and safety of the on‐demand use of paroxetine, dapoxetine, sildenafil and combined dapoxetine with sildenafil in treatment of patients with premature ejaculation (PE).
Mohammed Abu El-Hamd, A. Abdelhamed
semanticscholar   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Sildenafil suppresses Inflammation-driven Colorectal Cancer in mice

Cancer Prevention Research, 2017
Intestinal cyclic guanosine monophosphate (cGMP) signaling regulates epithelial homeostasis and has been implicated in the suppression of colitis and colon cancer. In this study, we investigated the cGMP-elevating ability of the phosphodiesterase-5 (PDE5)
B. Islam, Sarah K. Sharman, Yali Hou, Allison E. Bridges, Nagendra Singh, Sangmi Kim, R. Kolhe, J. Trillo-Tinoco, P. Rodriguez, F. Berger, S. Sridhar, D. Browning   +11 more
semanticscholar   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Rethinking Reproductive Governance: What Can Public Administration on the Island of Ireland Learn From Abortion Accompaniment?

Public Administration, EarlyView.
ABSTRACT The recent decriminalization of abortion marked a crucial step toward improved reproductive care on the island of Ireland. However, this has not translated into fully accessible abortion provision—barriers, including inaccessible services, persist, leaving gaps that public administration has not formally addressed. In response, informal actors,
Anna Theresa Schmid
wiley   +1 more source