Results 71 to 80 of about 28,609 (228)

Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth. [PDF]

, 2016
Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat erectile dysfunction, has been linked to an increased risk of melanoma. Here, we have examined the potential connection between cGMP-dependent signaling cascades and
Liu, He, Robert E. Hunger, Sandeep Dhayade, Ulrike Naumann, Thunemann, Martin, Susanne Kaesler, Biedermann, Tilo, Sinnberg, Tobias, He Liu, Stefanie Peters, Schittek, Birgit, Susanne Feil, Kaesler, Susanne, Hunger, Robert E., Feil, Robert, Naumann, Ulrike, Dobrowinski, Hyazinth, Hyazinth Dobrowinski, Birgit Schittek, Simon, Hans-Uwe, Hans-Uwe Simon, Peters, Stefanie, Martin Thunemann, Feil, Susanne, Tobias Sinnberg, Dhayade, Sandeep, Tilo Biedermann, Robert Feil   +27 more
core   +2 more sources

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Pretreatment of sildenafil attenuates ischemia-reperfusion renal injury in rats [PDF]

, 2009
Sildenafil was the first selective inhibitor of phosphodiesterase-5 (PDE5) to be widely used for treating erectile dysfunction. Many recent studies have investigated the cardioprotective role of sildenafil in animal models.
임범진
core   +1 more source

Development of a physiologically‐based pharmacokinetic model for Ritonavir characterizing exposure and drug interaction potential at both acute and steady‐state conditions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 523-539, March 2025.
Abstract Ritonavir (RTV) is a potent CYP3A inhibitor that is widely used as a pharmacokinetic (PK) enhancer to increase exposure to select protease inhibitors. However, as a strong and complex perpetrator of CYP3A interactions, RTV can also enhance the exposure of other co‐administered CYP3A substrates, potentially causing toxicity.
Lien Thi Ngo, Woojin Jung, Tham Thi Bui, Hwi‐yeol Yun, Jung‐woo Chae, Jeremiah D. Momper   +5 more
wiley   +1 more source

A Retrospective Review of Infants Receiving Sildenafil

, 2018
OBJECTIVE The purpose of the study was to assess mortality in an infant population receiving sildenafil. METHODS A retrospective review of hospitalized infants at Children's Hospital Los Angeles who received sildenafil between 2008 and ...
Stanley Azen, Roberta M. Kato, Payal Shah, Shazia Bhombal, Jacqueline Szmuszkovicz, Aliva De   +5 more
core   +1 more source

Erectile dysfunction - an update of current practice and future strategies [PDF]

, 2013
Erectile dysfunction (ED) is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse.1 Up to 150 million men worldwide suffer from ED and this figure is likely to double by the year 2025.2 A number
Asif Muneer, Muneer, A, Jas Kalsi, Kalsi, J   +3 more
core   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Clinical deterioration after sildenafil cessation in patients with pulmonary hypertension

, 2008
Anne M Keogh, Andrew Jabbour, Christopher S Hayward, Peter S MacdonaldHeart Lung Transplant Unit, St Vincent’s Hospital, Sydney, New South Wales, AustraliaAbstract: Sildenafil is a selective inhibitor of phosphodiesterase type 5 (PDE-5).
Peter S Macdonald, Christopher S Hayward, Anne M Keogh, Andrew Jabbour   +3 more
core  

6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human

Andrology, EarlyView.
ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel, Fabio Henrique da Silva, Jéssica Mariana Dias, Luise Gabriela Santos Pereira, Douglas Rafael Martins Dias, Amanda Bueno Olivotti, André Almeida Schenka, Valéria Barbosa de Souza, Masato Tsutsui, Fabiola Zakia Monica, Edson Antunes, Gilberto De Nucci, Mariana G. de Oliveira   +12 more
wiley   +1 more source

Erektil Disfonksiyonlu Hastalarda Sildenafil Tedavisini Birakma Nedenleri [PDF]

, 2005
Introduction: Although there are many methods in the treatment of erectile dysfunction, no one is successful and sufficient in all the patients. Sildenafil treatment has been found the most successful method among ED treatments. In spite of high efficacy
Tuğlu D., Tekdoğan Ü.Y., Güngör S., Başar M.M., Akbulut Z., Atan A.   +5 more
core   +1 more source