Results 51 to 60 of about 35,832 (220)

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source

The effect of sildenafil on maternal mortality and fetal adverse outcomes among pregnant patients with congenital heart disease-associated pulmonary artery hypertension: A retrospective cohort study

Annals of Pediatric Cardiology
Background and Aim: Maternal and fetal mortality in patients with congenital heart disease-associated pulmonary artery hypertension (CHD-PAH) is reported to be quite high. Sildenafil is the standard of care in PAH.
Nabila Sabri Nahdi, Anggoro Budi Hartopo, Dyah Wulan Anggrahini, Irwan Taufiqur Rachman, Lucia Kris Dinarti   +4 more
doaj   +1 more source

Sildenafil reduces insulin-resistance in human endothelial cells. [PDF]

PLoS ONE, 2011
BACKGROUND: The efficacy of Phosphodiesterase 5 (PDE5) inhibitors to re-establish endothelial function is reduced in diabetic patients. Recent evidences suggest that therapy with PDE5 inhibitors, i.e.
Caterina Mammi, Donatella Pastore, Marco F Lombardo, Francesca Ferrelli, Massimiliano Caprio, Claudia Consoli, Manfredi Tesauro, Lucia Gatta, Massimo Fini, Massimo Federici, Paolo Sbraccia, Giulia Donadel, Alfonso Bellia, Giuseppe M Rosano, Andrea Fabbri, Davide Lauro   +15 more
doaj   +1 more source

Sildenafil Reduces Neointimal Hyperplasia after Angioplasty and Inhibits Platelet Aggregation via Activation of cGMP-dependent Protein Kinase

Scientific Reports, 2019
Sildenafil is known to reduce cardiac hypertrophy through cGMP-dependent protein kinase (cGK) activation. Studies have demonstrated that cGK has a central switching role in modulating vascular smooth muscle cell (VSMC) phenotype in response to vascular ...
Han-Mo Yang, Sooryeonhwa Jin, Hyunduk Jang, Juyoung Kim, Joo-Eun Lee, Joonoh Kim, Hyo‐Soo Kim   +6 more
semanticscholar   +1 more source

Interventional therapies for chronic heart failure: An overview of recent developments

ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.
Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo, Si Shi, Yutong Guo, Jie Xiong, Bo Wang, Zengxiang Dong, Dianyu Gao, Yingfeng Tu   +7 more
wiley   +1 more source

The Physicochemical Compatibility of Sildenafil Injection with Parenteral Medications Used in Neonatal Intensive Care Settings

Pharmaceutics
Sildenafil is used to treat pulmonary hypertension in neonatal intensive care unit (NICU) settings. As multiple intravenous (IV) medications are co-administered in NICU settings, we sought to investigate the physicochemical compatibility of sildenafil ...
D. Thisuri N. De Silva, Tobias Strunk, Michael Petrovski, Madhu Page-Sharp, Brioni R. Moore, Kevin T. Batty   +5 more
doaj   +1 more source

The effect of sesame intake on adult albino rat testis during sildenafil long-term administration

Journal of Basic and Applied Zoology, 2021
Background Sildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies. Unfortunately, chronic administration of sildenafil negatively affects fertility.
M. Goweder Fawzia, T. M. Abu El-Nasr, A. A. El-Sayed   +2 more
doaj   +1 more source

Cilostazol in patients with heart failure and preserved ejection fraction—The CLIP‐HFpEF trial

ESC Heart Failure, Volume 12, Issue 2, Page 1437-1446, April 2025.
• Cilostazol is an oral PDE‐3 inhibitor that may have advantageous effects in heart failure with preserved ejection fraction (HFpEF). • Cilostazol significantly improved short‐term heart failure‐related health status scores (KCCQ‐12) and NT‐proBNP levels when compared to placebo.
Norman Aiad, Jeanne du Fay de Lavallaz, Michael J. Zhang, Thanat Chaikijurajai, Bo Ye, Prabhjot S. Nijjar, Julie A. Lahiri, Cindy M. Martin, Tamas Alexy, Markus Meyer   +9 more
wiley   +1 more source

Development and characterization of polymer-coated liposomes for vaginal delivery of sildenafil citrate

Drug Delivery, 2017
Vaginal administration of sildenafil citrate has shown recently to develop efficiently the uterine lining with subsequent successful embryo implantation following in vitro fertilization.
H. Refai, Doaa H. Hassan, Rehab Abdelmonem   +2 more
semanticscholar   +1 more source

The clinical case of sildenafil administration in a very premature infant with pulmonary hypertension

Journal of Pediatric and Neonatal Individualized Medicine, 2015
We report the use of oral sildenafil in a 7-month-old preterm newborn with severe bronchopulmonary dysplasia and pulmonary arterial hypertension refractory to captopril and inhaled budesonide, and need of consistent oxygenation.
Galina A. Alyamovskaya, Elena S. Keshishian, Elena G. Verchenko, Vera V. Bereznitskaya   +3 more
doaj   +1 more source