Results 41 to 50 of about 59,140 (257)

Sildenafil-evoked photoreceptor oxidative stress in vivo is unrelated to impaired visual performance in mice.

PLoS ONE, 2021
PurposeThe phosphodiesterase inhibitor sildenafil is a promising treatment for neurodegenerative disease, but it can cause oxidative stress in photoreceptors ex vivo and degrade visual performance in humans.
Bruce A Berkowitz, Robert H Podolsky, Karen Lins Childers, Aicha Saadane, Timothy S Kern, Robin Roberts, Hailey Olds, Joydip Joy, Collin Richards, Tilman Rosales, Michael Schneider, Brennan Schilling, Arthur Orchanian, Emma Graffice, Kenan Sinan, Haohua Qian, Lamis Harp   +16 more
doaj   +1 more source

STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early‐onset fetal growth restriction

BJOG: an International Journal of Obstetrics and Gynaecology, 2019
To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies with early‐onset fetal growth restriction.
K. Groom, K. Groom, L. Mccowan, L. Mccowan, L. Mackay, Arier C. Lee, G. Gardener, J. Unterscheider, J. Unterscheider, R. Sekar, J. Dickinson, J. Dickinson, Peter Muller, Rosemary Reid, D. Watson, A. Welsh, A. Welsh, Jay Marlow, S. Walker, S. Walker, J. Hyett, J. Hyett, J. Morris, P. Stone, P. Baker, P. Baker   +25 more
semanticscholar   +1 more source

Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis [PDF]

, 2017
Background: Phosphodiesterases (PDE) are a superfamily of enzymes that hydrolyse cyclic nucleotides (cAMP/ cGMP), signal molecules in transduction pathways regulating crucial aspects of cell life.
Biagioni, Stefano, Cardarelli, Silvia, Giorgi, Mauro, Malatesta, Francesco, Naro, Fabio, Saliola, Michele   +5 more
core   +1 more source

Under pressure: pulmonary hypertension associated with left heart disease. [PDF]

, 2015
© ERS 2015.Pulmonary hypertension (PH) associated with left heart disease (PH-LHD) is the most common type of PH, but its natural history is not well understood.
Farber, HW, Gibbs, S
core   +2 more sources

Impact of Mitochondrial Ca2+-Sensitive Potassium (mBKCa) Channels in Sildenafil-Induced Cardioprotection in Rats.

PLoS ONE, 2015
BackgroundMitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels are involved in myocardial ischemic preconditioning. Their role in sildenafil-induced cardioprotection is unknown.
Friederike Behmenburg, Marianne Dorsch, Ragnar Huhn, David Mally, André Heinen, Markus W Hollmann, Marc M Berger   +6 more
doaj   +1 more source

Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial.

The Lancet Child & Adolescent Health, 2017
BACKGROUND Severe early-onset fetal growth restriction can lead to a range of adverse outcomes including fetal or neonatal death, neurodisability, and lifelong risks to the health of the affected child.
A. Sharp, C. Cornforth, R. Jackson, J. Harrold, M. Turner, L. Kenny, P. Baker, E. Johnstone, A. Khalil, P. von Dadelszen, A. Papageorghiou, Z. Alfirevic   +11 more
semanticscholar   +1 more source

The effect of sesame intake on adult albino rat testis during sildenafil long-term administration

Journal of Basic and Applied Zoology, 2021
Background Sildenafil (Viagra) is widely used for the treatment of erectile dysfunction under various etiologies. Unfortunately, chronic administration of sildenafil negatively affects fertility.
M. Goweder Fawzia, T. M. Abu El-Nasr, A. A. El-Sayed   +2 more
doaj   +1 more source

Sildenafil citrate effects on seminal parameters in male participants with idiopathic infertility; A randomized, double-blind, controlled cross-over clinical trial study

Urological Science, 2022
Purpose: Sildenafil is a phosphodiesterase Type 5 inhibitor, which is a powerful and effective therapy for male erectile dysfunction (ED) and enables to restore temporary ED.
Gholamreza Mokhtari, Ali Hamidi Madani, Ehsan Kazemnezhad Leyli, Alireza Jafari   +3 more
doaj   +1 more source

Sildenafil Use in Children with Pulmonary Hypertension

Jornal de Pediatria, 2019
Objective To assess the demographics, treatment algorithm, and outcomes in a large cohort of children treated with sildenafil. Study design A retrospective cohort study of children with pulmonary hypertension (PH) treated with sildenafil at a single ...
Jennifer L. Cohen, S. Nees, Gerson A. Valencia, E. Rosenzweig, U. Krishnan   +4 more
semanticscholar   +1 more source

Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]

, 2016
Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio, Bimonte, V. M., Fittipaldi, Simona, Francomano, Davide, Greco, E. A., Lenzi, Andrea, Migliaccio, S., Papa, V., Wannenes, F.   +8 more
core   +1 more source