Results 31 to 40 of about 35,832 (220)

Sildenafil does not reliably improve exercise performance in hypoxia: a systematic review

BMJ Open Sport & Exercise Medicine, 2019
Objective Sildenafil is a pulmonary vasodilator that may reduce the decrement in endurance performance in moderate hypoxia. We assessed the efficacy of sildenafil to improve performance in hypoxia.Data sources/eligibility Criteria We systematically ...
Eric Alexander Carter, Keith Lohse, William Sheel, Michael Koehle   +3 more
doaj   +1 more source

Potential Protective Role of Nigella sativa Linn against Sildenafil Induced Hepatotoxicity and Nephrotoxicity in Adult Male Rabbits [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2018
Introduction: Nigella sativa is considered to have antioxidant components though it is proposed to have hepatoprotective and nephroprotective effect. Aim of the study: This study aimed to investigate hepatotoxic and nephrotoxic effects of sildenafil and ...
Elsayed Abouelnour, Mohammad Shaban, Ibrahim Elhalfawy, Mofrih Hegazy   +3 more
doaj   +1 more source

Sildenafil and bosentan plasma concentrations in a human immunodeficiency virus-infected patient with pulmonary arterial hypertension treated with ritonavir-boosted protease inhibitor

Infectious Disease Reports, 2015
Sildenafil and bosentan are increasingly used for the treatment of pulmonary arterial hypertension (PAH) in HIV-infected patients. However, concerns exist about pharmacokinetic interactions among sildenafil, bosentan and antiretroviral drugs, including ...
Pierangelo Chinello, Stefania Cicalini, Simona Pichini, Roberta Pacifici, Massimo Tempestilli, Maria P. Cicini, Leopoldo P. Pucillo, Nicola Petrosillo   +7 more
doaj   +1 more source

Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial

European Heart Journal, 2017
Aims We aimed to determine whether treatment with sildenafil improves outcomes of patients with persistent pulmonary hypertension (PH) after correction of valvular heart disease (VHD).
Javier Bermejo, R. Yotti, R. García-Orta, P. Sánchez‐Fernández, Mario Castaño, J. Segovia-Cubero, P. Escribano-Subías, J. S. San Román, Xavier Borrás, Angel Alonso‐Gómez, J. Botas, M. Crespo-Leiro, Sonia Velasco, A. Bayés-Genís, A. López, R. Muñoz-Aguilera, E. de Teresa, J. González-Juanatey, Arturo Evangelista, T. Mombiela, A. González-Mansilla, J. Elízaga, Javier Martín-Moreiras, J. González-Santos, E. Moreno-Escobar, F. Fernández‐Avilés, Javier Raquel Teresa Ana Jaime José A Esther Candelas Ric Bermejo Yotti Mombiela Gónzález-Mansilla Elízaga G, Javier Bermejo, R. Yotti, T. Mombiela, A. González-Mansilla, J. Elízaga, J. García-Robles, E. Pérez-David, Candelas Pérez del Villar, R. Sanz, Enrique Gutiérrez-Ibañes, M. Vázquez, A. Mur, Y. Benito, P. Martínez‐Legazpi, A. Barrio, A. Vázquez, R. García-Orta, Inés Uribe, Mercedes González, Pedro Luis Sánchez, J. González-Santos, Javier Martín-Moreiras, A. Arribas, M. M. Clemente Lorenzo, Alejandro Diego Nieto, Mario Castaño, A. Pérez de Prado, D. Alonso, J. Segovia-Cubero, M. Gómez-Bueno, I. Sayago Silva, M. Ángel Cavero, P. Escribano-Subías, L. Dominguez, R. Tello de Meneses, M. R. Ruiz Cano, Carmen Jiménez López-Guarch, J. S. San Román, P. Mota, Xavier Borrás, C. Amorós Galitó, Angel Alonso‐Gómez, M. C. Bello Mora, D. Mesa Rubio, J. Botas, R. Campuzano, M. Crespo-Leiro, R. Marzoa, J. Cuenca, Sonia Velasco, R. Muñoz, V. Suberviola, C. Beltrán Herrera, L. Mora, M. Mar Sarrión, D. Vaqueriza, A. Bayés-Genís, E. Ferrer, J. González-Juanatey, B. Cid, A. M. Monzonís, A. López, J. M. F. Arizón de Prado, M. Santisteban, Arturo Evangelista, D. Garcia-Dorado, E. de Teresa, M. Jiménez-Navarro, Fernando Carrasco Chinchilla, E. Moreno-Escobar, J. Alonso   +97 more
semanticscholar   +1 more source

STRIDER NZAus: a multicentre randomised controlled trial of sildenafil therapy in early‐onset fetal growth restriction

BJOG: an International Journal of Obstetrics and Gynaecology, 2019
To assess the effect of maternal sildenafil therapy on fetal growth in pregnancies with early‐onset fetal growth restriction.
K. Groom, K. Groom, L. Mccowan, L. Mccowan, L. Mackay, Arier C. Lee, G. Gardener, J. Unterscheider, J. Unterscheider, R. Sekar, J. Dickinson, J. Dickinson, Peter Muller, Rosemary Reid, D. Watson, A. Welsh, A. Welsh, Jay Marlow, S. Walker, S. Walker, J. Hyett, J. Hyett, J. Morris, P. Stone, P. Baker, P. Baker   +25 more
semanticscholar   +1 more source

Nocturnal penile erections: A retrospective study of the role of RigiScan in predicting the response to sildenafil in erectile dysfunction patients

Journal of Advanced Research, 2018
Sildenafil enhances the nitric oxide–cGMP pathway of erection, which is claimed to have a role in nocturnal penile tumescence and rigidity (NPTR). This study aimed to find whether RigiScan can predict the response to sildenafil among erectile dysfunction
Samir M. Elhanbly, Mamdouh M. Abdel-gawad, Ayman A. Elkholy, Ahmed F. State   +3 more
doaj   +1 more source

Effect of sildenafil added to antifibrotic treatment in idiopathic pulmonary fibrosis

Scientific Reports, 2021
Sildenafil is a phosphodiesterase-5 inhibitor used to treat idiopathic pulmonary arterial hypertension; however, its benefits are unclear in patients with advanced idiopathic pulmonary fibrosis (IPF).
Jieun Kang, Jin Woo Song
doaj   +1 more source

Acute effect of sildenafil on myocardial ischemic territories in patients with stable coronary artery disease

The Egyptian Heart Journal, 2014
Objectives: To test the safety of sildenafil in patients with stable coronary artery disease (CAD). Methods: Sixty-one patients with stable CAD, documented by coronary angiography were included in this phase I study.
Mohamed Salem, Ahmed Bendary, Shaimaa Moustafa, Ahmed Ramzy, Osama Sanad   +4 more
doaj   +1 more source

Maternal sildenafil for severe fetal growth restriction (STRIDER): a multicentre, randomised, placebo-controlled, double-blind trial.

The Lancet Child & Adolescent Health, 2017
BACKGROUND Severe early-onset fetal growth restriction can lead to a range of adverse outcomes including fetal or neonatal death, neurodisability, and lifelong risks to the health of the affected child.
A. Sharp, C. Cornforth, R. Jackson, J. Harrold, M. Turner, L. Kenny, P. Baker, E. Johnstone, A. Khalil, P. von Dadelszen, A. Papageorghiou, Z. Alfirevic   +11 more
semanticscholar   +1 more source

A Retrospective Study of Sildenafil Administration in 55 Cats with Cardiopulmonary Disease (2009–2021)

Animals
Sildenafil is a drug used to successfully manage a variety of cardiopulmonary disorders in people and dogs, but there is limited information on its use in cats.
Jasmine Huynh, Samantha Dolan, Emily T. Karlin, Lisa M. Freeman, Elizabeth A. Rozanski, John E. Rush   +5 more
doaj   +1 more source