Results 11 to 20 of about 59,140 (257)

Placental effects and transfer of sildenafil in healthy and preeclamptic conditionsResearch in context

EBioMedicine, 2019
Background: The phosphodiesterase-5 inhibitor (PDE5) sildenafil has emerged as a promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted due to lack of effect and increased neonatal morbidity.
Emilie Hitzerd, Michelle Broekhuizen, Katrina M. Mirabito Colafella, Marija Glisic, René de Vries, Birgit C.P. Koch, Michiel A. de Raaf, Daphne Merkus, Sam Schoenmakers, Irwin K.M. Reiss, A.H. Jan Danser, Sinno H.P. Simons   +11 more
doaj   +2 more sources

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers

Drug Design, Development and Therapy, 2017
Milko Radicioni,1 Chiara Castiglioni,1 Andrea Giori,2 Irma Cupone,3 Valeria Frangione,4 Stefano Rovati4 1CROSS Research S.A., Phase I Unit, Arzo, Switzerland; 2IBSA Farmaceutici Italia, Lodi, Italy; 3Bouty S.p.A., Strada Padana Superiore, Cassina De ...
Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S   +5 more
doaj   +2 more sources

A real‐world pharmacovigilance study of FDA adverse event reporting system events for sildenafil

Andrology, 2023
Sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5), is widely used for the treatment of erectile dysfunction (ED). However, the safety profile of sildenafil, including adverse event (AEs), requires comprehensive evaluation.
Y. Wang, Bin Zhao, Haiyan Yang, Zheng Wan   +3 more
semanticscholar   +1 more source

Visual Side Effects Linked to Sildenafil Consumption: An Update

Biomedicines, 2021
Phosphodiesterase type 5 (PDE5) inhibitors such as Viagra® (sildenafil citrate) have demonstrated efficacy in the treatment of erectile dysfunction (ED) by inducing cyclic guanosine monophosphate (cGMP) elevation followed by vasodilation and increased ...
Eva Ausó, V. Gómez-Vicente, Gema Esquiva   +2 more
semanticscholar   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Maternal Sildenafil vs Placebo in Pregnant Women With Severe Early-Onset Fetal Growth Restriction

JAMA Network Open, 2020
Key Points Question Does sildenafil reduce the risk of perinatal mortality or morbidity in children of pregnant women with severe early onset fetal growth restriction?
A. Pels, J. Derks, A. Elvan‐Taşpınar, J. van Drongelen, M. D. de Boer, H. Duvekot, J. V. van Laar, J. van Eyck, S. Al-Nasiry, M. Sueters, M. Post, W. Onland, A. V. van Wassenaer-Leemhuis, C. Naaktgeboren, J. Jakobsen, C. Gluud, R. Duijnhoven, Titia Lely, S. Gordijn, W. Ganzevoort   +19 more
semanticscholar   +1 more source

Efficacy and safety of sildenafil added to pirfenidone in patients with advanced idiopathic pulmonary fibrosis and risk of pulmonary hypertension: a double-blind, randomised, placebo-controlled, phase 2b trial.

The Lancet Respiratory Medicine, 2020
BACKGROUND The benefit of sildenafil in patients with advanced idiopathic pulmonary fibrosis (IPF) at risk of poor outcomes from pulmonary hypertension, whether already present or likely to develop, is uncertain.
J. Behr, S. Nathan, W. Wuyts, N. Mogulkoc Bishop, D. Bouros, K. Antoniou, J. Guiot, M. Kramer, K. Kirchgaessler, M. Bengus, F. Gilberg, A. Perjesi, S. Harari, A. Wells   +13 more
semanticscholar   +1 more source

The phosphodiesterase 5 inhibitor sildenafil decreases the proinflammatory chemokine IL-8 in diabetic cardiomyopathy: in vivo and in vitro evidence [PDF]

, 2019
Purpose: Interleukin (IL)-8 is a proinflammatory C-X-C chemokine involved in inflammation underling cardiac diseases, primary or in comorbid condition, such diabetic cardiomyopathy (DCM).
Antinozzi, C., Basili, S., Colletti, M., Corinaldesi, C., Crescioli, C., Di Luigi, L., Filardi, T., Giannattasio, S., Lenzi, A., Morano, S., Scolletta, S.   +10 more
core   +1 more source

Mechanisms involved in the remyelinating effect of sildenafil [PDF]

, 2018
Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela, García, Agustina, Gutierrez-Mecinas, María, Martínez-Sánchez, José Lupicinio, Moreno, Beatriz, Pifarré, Paula   +5 more
core   +1 more source

Sildenafil for the Treatment of Alzheimer’s Disease: A Systematic Review

Journal of Alzheimer's disease reports, 2020
Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in Alzheimer’s disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is upregulated. Sildenafil inhibits PDE5 and increases cGMP levels.
O. Sanders
semanticscholar   +1 more source