Results 21 to 30 of about 35,832 (220)

Efficacy and safety of sildenafil added to pirfenidone in patients with advanced idiopathic pulmonary fibrosis and risk of pulmonary hypertension: a double-blind, randomised, placebo-controlled, phase 2b trial.

The Lancet Respiratory Medicine, 2020
BACKGROUND The benefit of sildenafil in patients with advanced idiopathic pulmonary fibrosis (IPF) at risk of poor outcomes from pulmonary hypertension, whether already present or likely to develop, is uncertain.
J. Behr, S. Nathan, W. Wuyts, N. Mogulkoc Bishop, D. Bouros, K. Antoniou, J. Guiot, M. Kramer, K. Kirchgaessler, M. Bengus, F. Gilberg, A. Perjesi, S. Harari, A. Wells   +13 more
semanticscholar   +1 more source

Evaluation of cardiac injury biomarkers in serum following concomitant administration of sildenafil citrate with dextromethorphan and chlorpheniramine in rat [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2021
Sildenafil citrate is an inhibitor of the enzyme phosphodiesterase 5, dextromethorphan is an antitussive with weak opioid effects, and chlorpheniramine is a first-generation antihistamine.
Rasol Sadeghy, B. Amouoghli Tabrizi, majid fartashvand   +2 more
doaj   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Sildenafil for the Treatment of Alzheimer’s Disease: A Systematic Review

Journal of Alzheimer's disease reports, 2020
Nitric oxide/cyclic guanosine monophosphate (cGMP) signaling is compromised in Alzheimer’s disease (AD), and phosphodiesterase 5 (PDE5), which degrades cGMP, is upregulated. Sildenafil inhibits PDE5 and increases cGMP levels.
O. Sanders
semanticscholar   +1 more source

Effect of Maternal Sildenafil Supplementation During Gestation on the Reproductive Performance of Sows/Gilts and Growth Performance of Neonatal Piglets

Frontiers in Veterinary Science, 2022
Sildenafil, a phosphodiesterase 5 (PDE-5) inhibitor, provides an alternative and effective strategy to increase uterine blood flow and vascular development, thus improving fetal development.
Yue Wang, Yusheng Qin, Wei Zhao, Fusheng Yao, Wenjing Wang, Xiao Hu, Linghua Cheng, Lei An, Jianhui Tian   +8 more
doaj   +1 more source

Effect of sildenafil citrate on treatment of infertility in women with a thin endometrium: a systematic review and meta-analysis

Journal of International Medical Research, 2020
Objective Endometrial thickness is a prognostic factor for successful pregnancy. This meta-analysis aimed to examine the role of sildenafil citrate on infertile women with a thin endometrium.
Xin Li, Ting Luan, Chun Zhao, Mianqiu Zhang, Li-ping Dong, Yan Su, X. Ling   +6 more
semanticscholar   +1 more source

Oral bioavailability and pharmacokinetics of sildenafil citrate dry foam tablets in rats

Cogent Medicine, 2018
Sildenafil has low water solubility and oral bioavailability. Dry foam formulations of solid dosage forms of poorly water-soluble drugs may exhibit improved dissolution and bioavailability.
Somchai Sawatdee, Apichart Atipairin, Attawadee Sae Yoon, Teerapol Srichana, Narumon Changsan, Tan Suwandecha, Wirot Chanthorn, Atchara Phoem   +7 more
doaj   +1 more source

Central retinal vein and artery occlusion associated with sildenafil: a case report and review of the literature

Journal of Medical Case Reports, 2023
Background Sildenafil is a selective phosphodiesterase type 5 inhibitor used for the treatment of erectile dysfunction and pulmonary hypertension. It is available over the counter in many countries. While there have been a few reports of retinal vascular
Ali Torkashvand, Pasha Anvari, Siavash Ketabi, Esmaeil Asadi Khameneh   +3 more
doaj   +1 more source

Nintedanib plus Sildenafil in Patients with Idiopathic Pulmonary Fibrosis

New England Journal of Medicine, 2018
Background Nintedanib is an approved treatment for idiopathic pulmonary fibrosis (IPF). A subgroup analysis of a previously published trial suggested that sildenafil may provide benefits regarding oxygenation, gas exchange as measured by the diffusion ...
M. Kolb, G. Raghu, A. Wells, J. Behr, L. Richeldi, B. Schinzel, M. Quaresma, S. Stowasser, F. Martinez   +8 more
semanticscholar   +1 more source

EFFECTS OF SILDENAFIL ON THE TESTES OF THE NONDIABETIC AND DIABETIC ADULT ALBINO RATS (Light and Electron Microscopic Study) [PDF]

Al-Azhar International Medical Journal, 2022
Background: Sildenafil citrate is effective in men with erectile dysfunction. Sildenafil induces degenerative changes in seminiferous tubules and interstitial histological alterations.
El-Sayed Jahin, Mustafa Al-Jizawi, Fayez Abd-Elfattah   +2 more
doaj   +1 more source