Results 21 to 30 of about 28,609 (228)
EBioMedicine, 2019 Background: The phosphodiesterase-5 inhibitor (PDE5) sildenafil has emerged as a promising treatment for preeclampsia (PE). However, a sildenafil trial was recently halted due to lack of effect and increased neonatal morbidity.
Emilie Hitzerd +11 more
doaj +1 more source
Appropriateness of Sildenafil Prescribing in Pulmonary Hypertension with Valvular Heart Disease: A Single Centre Study [PDF]
Trends in Pharmaceutical Sciences, 2022 Oral sildenafil has proven efficacy in pulmonary hypertension in current clinical practice. However, there is a research gap in sildenafil prescribing among patients with valvular heart disease (VHD) and pulmonary hypertension (PH) in Malaysia.
Tze Hoon Goo +5 more
doaj +1 more source
Sildenafil does not reliably improve exercise performance in hypoxia: a systematic review
BMJ Open Sport & Exercise Medicine, 2019 Objective Sildenafil is a pulmonary vasodilator that may reduce the decrement in endurance performance in moderate hypoxia. We assessed the efficacy of sildenafil to improve performance in hypoxia.Data sources/eligibility Criteria We systematically ...
Eric Alexander Carter +3 more
doaj +1 more source
Potential Protective Role of Nigella sativa Linn against Sildenafil Induced Hepatotoxicity and Nephrotoxicity in Adult Male Rabbits [PDF]
Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2018 Introduction: Nigella sativa is considered to have antioxidant components though it is proposed to have hepatoprotective and nephroprotective effect. Aim of the study: This study aimed to investigate hepatotoxic and nephrotoxic effects of sildenafil and ...
Elsayed Abouelnour +3 more
doaj +1 more source
EFFECTS OF SILDENAFIL ON THE TESTES OF THE NONDIABETIC AND DIABETIC ADULT ALBINO RATS (Light and Electron Microscopic Study) [PDF]
Al-Azhar International Medical Journal, 2022 Background: Sildenafil citrate is effective in men with erectile dysfunction. Sildenafil induces degenerative changes in seminiferous tubules and interstitial histological alterations.
El-Sayed Jahin +2 more
doaj +1 more source
Infectious Disease Reports, 2015 Sildenafil and bosentan are increasingly used for the treatment of pulmonary arterial hypertension (PAH) in HIV-infected patients. However, concerns exist about pharmacokinetic interactions among sildenafil, bosentan and antiretroviral drugs, including ...
Pierangelo Chinello +7 more
doaj +1 more source
Journal of Advanced Research, 2018 Sildenafil enhances the nitric oxide–cGMP pathway of erection, which is claimed to have a role in nocturnal penile tumescence and rigidity (NPTR). This study aimed to find whether RigiScan can predict the response to sildenafil among erectile dysfunction
Samir M. Elhanbly +3 more
doaj +1 more source
Safety of Sildenafil in Infants* [PDF]
Pediatric Critical Care Medicine, 2014 In view of the recent U.S. Food and Drug Administration's warning against the use of sildenafil in pediatric patients, we aimed to provide an updated overview of the dosing and safety of sildenafil in infants and to explore the relevance of the present safety concerns to the infant population.The National Library of Medicine PubMed and Cochrane ...
Samiee-Zafarghandy S +2 more
openaire +4 more sources
The Egyptian Heart Journal, 2014 Objectives: To test the safety of sildenafil in patients with stable coronary artery disease (CAD). Methods: Sixty-one patients with stable CAD, documented by coronary angiography were included in this phase I study.
Mohamed Salem +4 more
doaj +1 more source
AnimalsSildenafil is a drug used to successfully manage a variety of cardiopulmonary disorders in people and dogs, but there is limited information on its use in cats.
Jasmine Huynh +5 more
doaj +1 more source