Results 61 to 70 of about 28,609 (228)

Preoperative subcutaneous sildenafil injection increases random flap survival in rats [PDF]

Acta Cirúrgica Brasileira, 2018
Purpose: To investigate the effect of subcutaneous sildenafil on random flap survival. Methods: Fourteen Wistar rats, which were divided in to two groups, were used for this experimental study.
Merdan Serin, Dincer Altinel, Cem Leblebici, Burcu Biltekin, Mert Celikten, Fatih Irmak, Sevgi Kurt Yazar   +6 more
doaj   +2 more sources

Why sildenafil and sildenafil citrate monohydrate crystals are not stable? [PDF]

, 2015
Sildenafil citrate was crystallized by various techniques aiming to determine the behavior and factors affecting the crystal growth. There are only 2 types of sildenafil obtaining from crystallization: sildenafil (1) and sildenafil citrate monohydrate (2)
Nitichai, Kwanjai, Pakawatchai, Chaveng, Phetmung, Hirihattaya, Srichana, Teerapol, Sawatdee, Somchai   +4 more
core   +1 more source

Network meta‐analysis of tocolytics in preterm labor: Establishing an evidence‐based treatment hierarchy

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Background The choice of tocolytic drugs is one of the most debated aspects of preterm birth management. Objective This network meta‐analysis aimed to establish an evidence‐based hierarchy for tocolytics used in preterm labor by evaluating their efficacy in delaying delivery, safety, and neonatal outcomes.
Barbara Gardella, Chiara Cassani, Vittoria Morteo, Alessandra Marmiroli, Mattia Dominoni, Arsenio Spinillo   +5 more
wiley   +1 more source

Current practices in the use of sildenafil for pulmonary arterial hypertension in Brazilian hospitals

BMC Research Notes, 2009
Background Sildenafil is a cyclic guanosine monophosphate-specific phosphodiesterase-5 inhibitor used for treating pulmonary hypertension. Although the use of sildenafil in patients under 18 years old is off-label, this inhibitor has been widely ...
Cabral Lucio M, de Souza Ana HA, Huf Gisele   +2 more
doaj   +1 more source

Sildenafil effects on blood pressures.

, 2013
Sildenafil (100 mg/kg d) effects on systolic blood pressures measured in conscious sham- and 2K1C-operated WT (WT-sham 118 ± 1 mmHg without, and 112 ± 1 mmHg with sildenafil; WT-2K1C 130 ± 4 mmHg without, and 118 ± 2 mmHg with sildenafil) and NO-GC1 KO ...
Ivo Quack (59626), Lars Christian Rump (485725), Sebastian Friedrich (485721), Sebastian A. Potthoff (485722), Kathrin Broekmans (485723), Miriam M. Cortese-Krott (485724), Johannes Stegbauer (485720), Evanthia Mergia (485727), Doris Koesling (485726)   +8 more
core   +1 more source

Sildenafil amplifies calcium influx and insulin secretion in pancreatic β cells

Physiological Reports
Sildenafil, a phosphodiesterase‐5 (PDE5) inhibitor, has been shown to improve insulin sensitivity in animal models and prediabetic patients. However, its other metabolic effects remain poorly investigated.
Naoya Murao, Risa Morikawa, Yusuke Seino, Kenju Shimomura, Yuko Maejima, Yuichiro Yamada, Atsushi Suzuki   +6 more
doaj   +1 more source

Sildenafil in Dialysis Patients

, 2006
Some of the highest rates of erectile dysfunction are seen in patients with renal failure, especially those on dialysis. The treatment of erectile dysfunction has been revolutionized in the last decade by the introduction of sildenafil.
P. Patel, R. Sam
core   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Cadmium-induced adrenal cortical autophagy in rats: possible modulation by sildenafil

Folia Morphologica, 2020
BACKGROUND: The link between autophagy, inflammatory bowel disease, ischaemic injury and cancer had been established. Reasonable evidence is available for cadmium to be related to certain cancers.
R. A. Imam, A. G. Motawei, W. A. Abd Algaleel   +2 more
doaj   +1 more source

Sildenafil prevents cardiovascular changes after bone marrow fat embolization in sheep

, 2007
BACKGROUND: Sudden, intraoperative cardiovascular deterioration as a result of pulmonary embolization of bone marrow fat is a potentially fatal complication during total hip and knee arthroplasty, intramedullary nailing, and spine surgery.
Aebli, N, Nuss, Katja D.V.M., Jörg Krebs, Leskosek, Boris, Hoerstrup, SP, Goss, Benjamin G., Nuss, Katja M, Goss, BG, Stephen J. Ferguson, Nikolaus Aebli, Krebs, J, Ben G. Goss, Boris Leskosek, Aebli, Nikolaus, Goss, Ben G, Nuss, K, Goss, B, Hoerstrup, Simon P., Katja Nuss, Ferguson, Stephen J, Ferguson, SJ, Ferguson, Stephen J., Krebs, Jörg, Hoerstrup, Simon P, Leskosek, B, Simon P. Hoerstrup   +25 more
core   +1 more source