Results 61 to 70 of about 19,757 (182)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Stimulating proteasomal degradation in human proteinopathies

The FEBS Journal, EarlyView.
The proteasome mediates the degradation of a wide range of proteins. Boosting proteasomal degradation may be beneficial in several disease contexts and can be achieved either by modulating proteasome activity or by improving substrate delivery. Proteasome activity can be enhanced by increasing proteasome abundance, inducing constitutive gate opening ...
Maria E. Gierisch, Enrica Barchi, Nico P. Dantuma   +2 more
wiley   +1 more source

The issue of recreational use of sildenafil

Journal of Education, Health and Sport
Introduction and purpose Erectile dysfunction (ED) is defined as the inability to achieve and maintain an erection sufficient for satisfactory sexual intercourse.
Krystian Wdowiak, Agnieszka Maciocha, Julia Wąż, Aleksandra Witas, Justyna Drogoń, Weronika Chachaj, Paulina Słomka, Edyta Gwóźdź, Dawid Konieczko, Ewa Gardocka   +9 more
doaj   +1 more source

Sildenafil Ameliorates Gentamicin-Induced Nephrotoxicity in Rats: Role of iNOS and eNOS

Journal of Toxicology, 2014
Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness is limited by its nephrotoxicity.
Mohamed A. Morsy, Salwa A. Ibrahim, Entesar F. Amin, Maha Y. Kamel, Rehab A. Rifaai, Magdy K. Hassan   +5 more
doaj   +1 more source

Effects and mechanisms of action of sildenafil citrate in human chorionic arteries

Reproductive Biology and Endocrinology, 2009
Objectives Sildenafil citrate, a specific phosphodiesterase-5 inhibitor, is increasingly used for pulmonary hypertension in pregnancy. Sildenafil is also emerging as a potential candidate for the treatment of intra-uterine growth retardation and for ...
Lynch Tadhg, O'Toole Daniel, Maharaj Chrisen H, Carney John, Jarman James, Higgins Brendan D, Morrison John J, Laffey John G   +7 more
doaj   +1 more source

The Sounds of Trust: The Bouba–Kiki Effect in Political Leaders' Names

Kyklos, EarlyView.
ABSTRACT Prior research has found evidence for the bouba–kiki effect according to which individuals associate sounds related to “bouba” and “kiki” with shapes and feelings. Using individual data from the World Values Survey, we investigate whether political leaders with names that sound “bouba” or “kiki” are associated with higher or lower trust.
Caroline Perrin, Laurent Weill
wiley   +1 more source

Bioequivalence study of a new sildenafil 100 mg orodispersible film compared to the conventional film-coated 100 mg tablet administered to healthy male volunteers

Drug Design, Development and Therapy, 2017
Milko Radicioni,1 Chiara Castiglioni,1 Andrea Giori,2 Irma Cupone,3 Valeria Frangione,4 Stefano Rovati4 1CROSS Research S.A., Phase I Unit, Arzo, Switzerland; 2IBSA Farmaceutici Italia, Lodi, Italy; 3Bouty S.p.A., Strada Padana Superiore, Cassina De ...
Radicioni M, Castiglioni C, Giori A, Cupone I, Frangione V, Rovati S   +5 more
doaj  

Rethinking Reproductive Governance: What Can Public Administration on the Island of Ireland Learn From Abortion Accompaniment?

Public Administration, EarlyView.
ABSTRACT The recent decriminalization of abortion marked a crucial step toward improved reproductive care on the island of Ireland. However, this has not translated into fully accessible abortion provision—barriers, including inaccessible services, persist, leaving gaps that public administration has not formally addressed. In response, informal actors,
Anna Theresa Schmid
wiley   +1 more source

“It's Not a One Size Fits All”: Service Users’ Views on How Service Structure Shapes Quality of Abortion Care in Britain. Findings from the SACHA Study.

Studies in Family Planning, EarlyView.
Abstract Abortion care in Britain has undergone significant transformation in recent years, with increasing use of medication, home management, and telemedicine. However, provision remains predominantly through specialist standalone clinics, particularly in England.
Rachel Scott, Maria Lewandowska, Rebecca Meiksin, Natasha Salaria, Patricia A. Lohr, Sharon Cameron, Jennifer Reiter, Melissa Palmer, Rebecca S. French, Kaye Wellings, the SACHA Study Team*   +10 more
wiley   +1 more source