Results 131 to 140 of about 1,073,059 (362)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Open Worship as Corporate Altar
, 1991 Excerpt: Open worship is one of those traditions Friends embrace, but often we do so without much thought as to how to use the time meaningfully. The tendency is to be uncomfortable with too much silence and to fill the empty space with words.
Anderson, Paul N.
core
The Thunder of the Marching Men of Joshua: Day 3 [PDF]
, 2015 Let us march on ballot boxes until the Wallaces of our nation tremble away in silence.... There is nothing wrong with marching in this sense.The Bible tells us that the mighty men of Joshua merely walked about the walled city of Jericho and the barriers ...
Rudy, John M.
core +1 more source
Break the Silence: The Movie Full Movie Free Download 2020
, 2020 Break the Silence: The Movie Full Movie Free Download 2020
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Small-scale silencing experiment in vegetative Euplotes crassus (provisional) v3
, 2017 Rachele Cesaroni
openalex +1 more source
Silencing of the Aleurone-specific Ltp2-gus Gene in Transgenic Rice is Reversed by Transgene Rearrangements and Loss of Aberrant Transcripts [PDF]
, 2004 Kazuko Morino +2 more
openalex +1 more source