Results 151 to 160 of about 206,958 (317)
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Silencing Conversational Silences
HypatiaAbstractThis paper aims to extend the discussion of silencing beyond the realm of speech and to the domain of conversational silences—that is, silences that have communicative functions in our conversational exchanges. I argue that, insofar as we can use silences to communicate, we can also be prevented from doing things with these silences.
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Tactical Silence in the Novels of Malika Mokeddem
Tactical Silence in the Novels of Malika Mokeddem, an inquiry into how silence may be used to challenge a gender-differentiated power system, relies on Michel de Certeaus model of strategies and tactics applied to a postcolonial assessment of both ...
Evans, Jane E.
core
Taide ja spiritualiteetti : teoksessa Moving the Silence
, 2013 Moving the Silence on taiteellis-pedagogisen opinnäytetyön kirjallinen osio taiteen ja spiritualiteetin välisestä dialogista. Työn pyrkimyksenä on löytää meditatiivisia tapoja toimia taiteen kentällä.
Arposalo, Eerika
core
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Great Sounds Seek Silence: Sonic and Visual Art Exhibition [PDF]
The exhibition presents works from local and international artists from Asia, Europe and the local London community for an interactive exhibition.
Liu, Vero
core
Ikala: Revista de Lenguaje y Cultura, 2011 This article presents some findings of a pragmalinguistic analysis of Gabriel García Márquez's Diatribe of Love against a Seated Man, specifically those related to politeness theory and conversation analysis. The analysis focuses on reproach and silence,
Víctor Julián Vallejo Zapata
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source