Results 141 to 150 of about 259,814 (293)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Beyond anxiety and face: strategic silence as instrumental disengagement in a Chinese graduate EAP Reading classroom. [PDF]

Front Psychol
Tian F.
europepmc   +1 more source

The Language of Silence

, 2015
The Language of Silence highlights the potential of silence as an active agent through which political exigencies may be explored. Through understated, sometimes deliberately obscured works, the exhibition presents poetic commentaries on current contexts
Sithole, Tawona, Li, Lin, Majali, Sulaïman   +2 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Code of Silence in Healthcare: Exploratory Cross-National Evidence and a Framework for Reporting and Responsibility. [PDF]

Health Serv Insights
Manev IM, Miaoulis G, Cumpat CM, Theodoru IC.   +3 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The mediating and moderating roles of surface acting and perceived organizational support in the relationship between perceived overqualification and silence behavior among young nurses: A cross-sectional study. [PDF]

PLoS One
Liu D, Zhou Q, Ma S, Zhang S, Liu Y, Zhang H, Li K, Chen C.   +7 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Silence as an Overlooked Catalyzer for Primate Vocal Evolution. [PDF]

Evol Anthropol
Lameira AR.
europepmc   +1 more source

“The Horror” of Silence: Gendered and Racial Absences in Joseph Conrad’s “Heart of Darkness” [PDF]

openThis thesis explores the racial and gendered silences in Joseph Conrad’s Heart of Darkness, examining how the novella reflects and reinforces the ideology of European imperialism. Drawing on historical context and postcolonial and feminist theory, it
POPOVA, VALERIIA
core