Results 181 to 190 of about 206,958 (317)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A formative evaluation of the Silence The Violence programme : a school-based violence prevention programme

, 2010
Includes summary.Includes bibliographical references (leaves 63-68).This report presents the findings of a formative evaluation of the Silence The Violence (STV) programme, a school-based violence prevention initiative. The programme is implemented by an
Phillips, Lynn
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A csend művészete Marguerite Duras műveiben

, 2019
Quand nous feuilletons un livre de Marguerite Duras, nous sommes possédés d’un sentiment extraordinaire. Nous pouvons imaginer l’écrivaine qui tape ses romans, ses pièces et il ne s’entend que les claquements de la machine à écrire mécanique ancienne. Et
Szeremeta, Ágnes Éva
core  

Neuronal silence as a predictive biomarker and target for epileptic seizures suppression. [PDF]

Sci Rep
Souza DLM, Bentivoglio LE, Gabrick EC, Protachevicz PR, Caldas IL, Iarosz KC, Dura-Bernal S, Batista AM, Borges FS.   +8 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Silence in physician clinical practice: a scoping review protocol. [PDF]

PLoS One
Kelly MA, Rivera S, McClurg C, Sweeney C, Mosca S, McLeod E, Bennett D, Brown M.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Silence, exit and the politics of piety: challenging logocentrism in political theory

, 2018
This chapter rejects the reduction of the phenomenon of silence in political life to violence. I the first section of the chapter we trace the reductive conceptualisation and subsequent lack of theoreti-cal engagement with the phenomenon of silence, to ...
Dingli, Sophia, Khalfey, Sameera
core  

Neural and behavioral responses to reproductive signals in male chorus frogs. [PDF]

J Exp Biol
Ochoa CB, Loeven AM, Fadool DA, Lemmon EM.   +3 more
europepmc   +1 more source