Results 71 to 80 of about 119,963 (269)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Después de la tragedia del Holocausto surgieron enormes interrogantes respecto a la pertinencia de su representación artística. En los estudios que se han realizado al respecto pueden distinguirse dos tendencias: una se dio en los años 60-80, y la otra ...
Rocío Garriga Inarejos
doaj +1 more source
The role and implications of mammalian cellular circadian entrainment
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley +1 more source
Silence in Arabic Cross-Cultural Interaction
This study investigates silence as a nonverbal manner of communication cross-culturally in Arabic to expose if it is as powerful as the verbal communication.
Atyaf Hasan Ibrahim +2 more
doaj
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
The value of openness in e-relationships: using Nonviolent Communication to guide online coaching and mentoring [PDF]
This paper explores the use of Nonviolent Communication (NVC) as a way of developing the openness needed for successful communication in e-mentoring relationships.
Elaine Cox, Patricia Dannahy
doaj
Cet article se penche sur les divers types de relations dans le roman Kuessipan de l’auteure innue Naomi Fontaine qui sont chargées d’amour décolonial. Ce concept, que Huberman établit à partir de Leanne Simpson, Junot Díaz et Chela Sandoval, envisage l ...
Isabella Huberman
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Silence! Silence! Silence! Someone is asking for help!
Não saber reconhecer quando se deve pedir o mayday pode ser um problema para o sucesso de resgate de um bombeiro. O sucesso do pedido de mayday vai aumentar com as ações proactivas do Comandante das Operações e das equipas no terreno, enquanto que o défice de formação leva a que a informação e os procedimentos importantes não sejam valorizados ...
Fidalgo, António, Fernandes, Ana Sá
openaire +1 more source

