Results 161 to 170 of about 192,601 (302)

Assessment of the RNA Silencing Suppressor Activity of Protein P0 of Pepper Vein Yellows Virus 5: Uncovering Natural Variability, Relevant Motifs and Underlying Mechanism. [PDF]

Biology (Basel), 2022
Pérez-Cañamás M, Bustos M, Puértolas V, Castelló Y, Peiró S, Hernández C.   +5 more
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Identification of an RNA Silencing Suppressor Encoded by a Symptomless Fungal Hypovirus, Cryphonectria Hypovirus 4. [PDF]

Biology (Basel), 2021
Aulia A, Hyodo K, Hisano S, Kondo H, Hillman BI, Suzuki N.   +5 more
europepmc   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Leek Yellow Stripe Virus Can Adjust for Host Adaptation by Trimming the N-Terminal Domain to Allow the P1 Protein to Function as an RNA Silencing Suppressor. [PDF]

Plant Pathol J, 2022
Sasaki J, Kawakubo S, Kim H, Kim OK, Yamashita K, Shimura H, Masuta C.   +6 more
europepmc   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Overexpression of an insect virus encoded silencing suppressor does not enhance plants' susceptibility to its natural virus. [PDF]

Virusdisease, 2021
Sinha KV, Jailani AK, Mandal B, Mukherjee SK, Sanan-Mishra N.   +4 more
europepmc   +1 more source

Poszt-transzkripcionális géncsendesítés és szupresszió molekuláris mechanizmusának feltárása növényekben = Unraveling the mechanism of Post-transcriptional gene silencing and suppression in plants [PDF]

, 2008
Az RNS silencing, egy géninaktivációs mechanizmus, amely szinte az összes eukarióta szervezetben működik, és magába foglalja az állati RNS interferencia és a növényi poszt-ranszkripcionális géncsendesítés (PTGS) jelenségét.
Burgyán, József, Molnár, Attila, Szittya, György, Várallyay, Éva   +3 more
core  

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, EarlyView.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Shallot virus X p42 Protein Expressed in Concert with Virus Movement Proteins Is a Suppressor of Two Plant Antiviral Defense Mechanisms

Plants
The genomes of viruses in the Allexivirus genus encode the p42 protein, which is considered the hallmark of the genus. The functions of p42 have not yet been studied experimentally and cannot be predicted based on sequence similarity, as p42-related ...
Denis A. Chergintsev, Alexander A. Lezzhov, Ekaterina A. Lazareva, Anastasia K. Atabekova, Anna D. Solovieva, Sergey Y. Morozov, Andrey G. Solovyev   +6 more
doaj   +1 more source