Results 11 to 20 of about 400,021 (291)

Constrained peptides mimic a viral suppressor of RNA silencing [PDF]

Nucleic Acids Research, 2021
Abstract The design of high-affinity, RNA-binding ligands has proven very challenging. This is due to the unique structural properties of RNA, often characterized by polar surfaces and high flexibility. In addition, the frequent lack of well-defined binding pockets complicates the development of small molecule binders.
Arne Kuepper, Niall M McLoughlin, Saskia Neubacher, Alejandro Yeste-Vázquez, Estel Collado Camps, Chandran Nithin, Sunandan Mukherjee, Lucas Bethge, Janusz M Bujnicki, Roland Brock, Stefan Heinrichs, Tom N Grossmann   +11 more
openaire   +9 more sources

Combined expression of p20 and p23 proteins from Citrus tristeza virus show enhanced local silencing suppressor activity [PDF]

Phytopathologia Mediterranea, 2016
Viruses developed a strategy to counter-defence the posttranscriptional gene silencing mechanism (PTGS) based on the activity of silencing suppressor proteins. Citrus tristeza virus (CTV), a member of the genus Closterovirus, has two suppressor proteins (
Ângela COSTA, Tatiana MARTINS, Natália MARQUES, Gustavo Nolasco   +3 more
doaj   +2 more sources

The Heterologous Expression of the p22 RNA Silencing Suppressor of the Crinivirus Tomato Chlorosis Virus from Tobacco Rattle Virus and Potato Virus X Enhances Disease Severity but Does Not Complement Suppressor-Defective Mutant Viruses

Viruses, 2017
To counteract host antiviral RNA silencing, plant viruses express suppressor proteins that function as pathogenicity enhancers. The genome of the Tomato chlorosis virus (ToCV) (genus Crinivirus, family Closteroviridae) encodes an RNA silencing suppressor,
Yazmín Landeo-Ríos, Jesús Navas-Castillo, Enrique Moriones, M. Carmen Cañizares   +3 more
doaj   +2 more sources

Distinct Effects of p19 RNA Silencing Suppressor on Small RNA Mediated Pathways in Plants. [PDF]

PLoS Pathogens, 2016
RNA silencing is one of the main defense mechanisms employed by plants to fight viruses. In change, viruses have evolved silencing suppressor proteins to neutralize antiviral silencing.
Levente Kontra, Tibor Csorba, Mario Tavazza, Alessandra Lucioli, Raffaela Tavazza, Simon Moxon, Viktória Tisza, Anna Medzihradszky, Massimo Turina, József Burgyán   +9 more
doaj   +3 more sources

Suppressors of Meiotic Silencing by Unpaired DNA [PDF]

Non-Coding RNA, 2019
Meiotic silencing by unpaired DNA (MSUD) is a gene silencing process that occurs within meiotic cells of Neurospora crassa and other fungi. We have previously developed a high-throughput screen to identify suppressors of this silencing pathway.
Hua Xiao, Thomas M. Hammond, Patrick K. T. Shiu   +2 more
doaj   +3 more sources

Silencing of a viral RNA silencing suppressor in transgenic plants

Journal of General Virology, 2002
High expression levels of the helper component proteinase (HCpro), a known virus suppressor of RNA silencing, were attained in Nicotiana benthamiana transformed with the HCpro cistron of Potato virus A (PVA, genus Potyvirus). No spontaneous silencing of the HCpro transgene was observed, in contrast to the PVA coat protein (CP)-encoding transgene in ...
Eugene I, Savenkov, Jari P T, Valkonen
openaire   +3 more sources

Identification of an RNA-silencing suppressor in the genome of Grapevine virus A

Journal of General Virology, 2006
Higher plants use post-transcriptional gene silencing (PTGS), an RNA-degradation system, as a defence mechanism against viral infections. To counteract this, plant viruses encode and express PTGS suppressor proteins. Four of the five proteins encoded by the Grapevine virus A (GVA) genome were screened using a green fluorescent protein (GFP)-based ...
ZHOU ZSH, DELL'ORCO M, SALDARELLI P, TURTURO C, MINAFRA A, MARTELLI GP   +5 more
openaire   +4 more sources

Suppressor of RNA silencing encoded by Beet yellows virus

Virology, 2003
Using an Agrobacterium-mediated transient assay, we screened the 15.5-kb genome of the Beet yellows virus for proteins with RNA silencing suppressor activity. Among eight proteins tested, only a 21-kDa protein (p21) was able to suppress double-stranded (ds) RNA-induced silencing of the green fluorescent protein (GFP) mRNA. Restoration of GFP expression
Reed, Jonathan C, Kasschau, Kristin D, Prokhnevsky, Alexey I, Gopinath, Kodetham, Pogue, Gregory P, Carrington, James C, Dolja, Valerian V   +6 more
openaire   +3 more sources

Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2. [PDF]

Front Microbiol, 2021
Geminiviruses are plant DNA viruses that infect a wide range of plant species and cause significant losses to economically important food and fiber crops. The single-stranded geminiviral genome encodes a small number of proteins which act in an orchestrated manner to infect the host.
Veluthambi K, Sunitha S.
europepmc   +5 more sources

A viral suppressor of gene silencing in plants [PDF]

Proceedings of the National Academy of Sciences, 1998
Gene silencing is an important but little understood regulatory mechanism in plants. Here we report that a viral sequence, initially identified as a mediator of synergistic viral disease, acts to suppress the establishment of both transgene-induced and virus-induced posttranscriptional gene silencing.
R, Anandalakshmi, G J, Pruss, X, Ge, R, Marathe, A C, Mallory, T H, Smith, V B, Vance   +6 more
openaire   +2 more sources