Results 31 to 40 of about 400,021 (291)

A calmodulin-like protein suppresses RNA silencing and promotes geminivirus infection by degrading SGS3 via the autophagy pathway in Nicotiana benthamiana.

PLoS Pathogens, 2017
A recently characterized calmodulin-like protein is an endogenous RNA silencing suppressor that suppresses sense-RNA induced post-transcriptional gene silencing (S-PTGS) and enhances virus infection, but the mechanism underlying calmodulin-like protein ...
Fangfang Li, Nan Zhao, Zhenghe Li, Xiongbiao Xu, Yaqin Wang, Xiuling Yang, Shu-Sheng Liu, Aiming Wang, Xueping Zhou   +8 more
doaj   +1 more source

Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter [PDF]

, 2010
The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine as a potent oncogenic factor;
Hiller, L, Monteverde, M, Louise Hiller, Shah, Reshma, Kalna, G., Karin A. Oien, Jonathan A. Cooper, Maurer, M.E., O'Brien, Darren I, Jelena Mann, Oien, KA, Frame, MC, Frame, Margaret C., David C. K. Chu, Crook, T., Chu, David C K, Lo Nigro, Cristiana, Lattanzio, L., Orange, Clare, Spender, Lindsay C., Chu, D.C.K., Thurlow, JK, Thurlow, Johanna K., Shah, R, Linda J. Nicholson, Syed, Nelofer, Harris, Adrian L, Orange, Cl., O'Brien, Darren I., Maurer, Meghan E., Shah, R., Nicholson, LJ, Hiller, Louise, Cooper, J.A., Inman, GJ, Monteverde, M., Mann, Jelena, Inman, Gareth J., Harris, AL., Syed, N, Cristiana Lo Nigro, Buffa, FM, Darren I. O’Brien, West, CML, Gasco, Milena, Smith, P, Crook, Tim, Monteverde, Martino, Meghan E. Maurer, Buffa, Francesca M., Kalna, Gabriela, O Brien, DI, Patridge, Max, Hannigan, A., Patridge, M., Paul Smith, Francesca M. Buffa, Cooper, Jonathan A, Mann, J, Oien, Karin A, Crook, T, Spender, Lindsay C.; id_orcid, Reshma Shah, Smith, Paul J., Lattanzio, L, Orange, C, Catharine M. L. West, Kalna, G, Cooper, JA, Max Patridge, Smith, Paul, Johanna K. Thurlow, Margaret C. Frame, Nicholson, Linda J., O'Brien, D.I., Spender, LC, and Gareth J. Inman, Buffa, Francesca M, O'Brien, Darren I., West, Catharine M L, Herrera, Blanca, Gasco, M., Adèle Hannigan, Smith, P., Frame, MC., Milena Gasco, Lo Nigro, C., Inman, Gareth J, Herrera, B, Oien, K.A., Frame, Margaret C, Laura Lattanzio, Gabriela Kalna, West, Catharine M. L., Nicholson, Linda J, Tim Crook, West, C.M.L., Nelofer Syed, Chu, DCK, Blanca Herrera, West, Catharine M L; id_orcid, Hannigan, Adèle, Thurlow, Johanna K, Mann, J., Spender, Lindsay C, Gasco, M, Clare Orange, Martino Monteverde, Patridge, M, Buffa, F.M., Maurer, Meghan E, David C.K. Chu, Chu, David C. K., Nicholson, L.J., Harris, AL, Spender, L.C., Lindsay C. Spender, Catharine M.L. West, Herrera, B., Hannigan, A, Maurer, ME, Cooper, Jonathan A., Oien, Karin A., Lo Nigro, C, Adrian L. Harris, Inman, G.J., Gareth J. Inman, Harris, Adrian L., Thurlow, J.K., Syed, N., Lattanzio, Laura   +130 more
core   +1 more source

The Role of Epstein-Barr Virus in Modulating Key Tumor Suppressor Genes in Associated Malignancies: Epigenetics, Transcriptional, and Post-Translational Modifications

Biomolecules, 2022
Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti, Michael Bright Yakass, Ernest Adjei Okertchiri, Samuel Mawuli Adadey, Osbourne Quaye   +4 more
doaj   +1 more source

Viral-Like Symptoms Induced by the Ectopic Expression of the p23 Gene of Citrus tristeza virus Are Citrus Specific and Do Not Correlate with the Pathogenicity of the Virus Strain

Molecular Plant-Microbe Interactions, 2005
Ectopic expression of the p23 gene from a severe (T36) strain of Citrus tristeza virus (CTV) induces viral-like symptoms in Mexican lime. Here, we report that expressing the same gene from a mild strain induced similar symptoms that correlated with ...
Carmen Fagoaga, Carmelo López, Pedro Moreno, Luis Navarro, Ricardo Flores, Leandro Peña   +5 more
doaj   +1 more source

Identification of the Potential Virulence Factors and RNA Silencing Suppressors of Mulberry Mosaic Dwarf-Associated Geminivirus

Viruses, 2018
Plant viruses encode virulence factors or RNA silencing suppressors to reprogram plant cellular processes or to fine-tune host RNA silencing-mediated defense responses.
Xiuling Yang, Yanxiang Ren, Shaoshuang Sun, Dongxue Wang, Fanfan Zhang, Dawei Li, Shifang Li, Xueping Zhou   +7 more
doaj   +1 more source

The VP3 factor from viruses of Birnaviridae family suppresses RNA silencing by binding both long and small RNA duplexes. [PDF]

PLoS ONE, 2012
RNA silencing is directly involved in antiviral defense in a wide variety of eukaryotic organisms, including plants, fungi, invertebrates, and presumably vertebrate animals.
Adrian Valli, Idoia Busnadiego, Varvara Maliogka, Diego Ferrero, José R Castón, José Francisco Rodríguez, Juan Antonio García   +6 more
doaj   +1 more source

Fungal Virus, FgHV1-Encoded p20 Suppresses RNA Silencing through Single-Strand Small RNA Binding

Journal of Fungi, 2022
Fungal viruses are widespread in fungi infecting plants, insects and animals. High-throughput sequencing has rapidly led to the discovery of fungal viruses. However, the interactive exploration between fungi and viruses is relatively limited.
Shuangchao Wang, Jingze Zhang, Clement Nzabanita, Mingming Zhang, Jianhua Nie, Lihua Guo   +5 more
doaj   +1 more source

Oomycete pathogens encode RNA silencing suppressors [PDF]

Nature Genetics, 2013
Effectors are essential virulence proteins produced by a broad range of parasites, including viruses, bacteria, fungi, oomycetes, protozoa, insects and nematodes. Upon entry into host cells, pathogen effectors manipulate specific physiological processes or signaling pathways to subvert host immunity.
Qiao, Yongli, Liu, Lin, Xiong, Qin, Flores, Cristina, Wong, James, Shi, Jinxia, Wang, Xianbing, Liu, Xigang, Xiang, Qijun, Jiang, Shushu, Zhang, Fuchun, Wang, Yuanchao, Judelson, Howard S., Chen, Xuemei, Ma, Wenbo   +14 more
openaire   +3 more sources

Plant viral suppressors of post‐transcriptional silencing do not suppress transcriptional silencing [PDF]

The Plant Journal, 2000
SummaryHomology‐dependent gene silencing is a regulatory mechanism that limits RNA accumulation from affected loci either by suppression of transcription (transcriptional gene silencing, TGS) or by activation of a sequence‐specific RNA degradation process (post‐transcriptional gene silencing, PTGS).
Marathe, M., Smith, T.H., Anandalakshmi, R., Bowman, L.H., Fagard, Mathilde, Mourrain, P., Vaucheret, Herve, Vance, V.B.   +7 more
openaire   +4 more sources

Orchid fleck dichorhavirus movement protein shows RNA silencing suppressor activity [PDF]

, 2022
To counteract RNA interference-mediated antiviral defence, virus genomes evolved to express proteins that inhibit this plant defence mechanism. Using six independent biological approaches, we show that orchid fleck dichorhavirus citrus strain (OFV-citrus)
Oliveira Leastro, Mikhail, Sánchez-Navarro, Jesús Ángel, Pallás Benet, Vicente   +2 more
core   +1 more source