Results 271 to 280 of about 192,601 (302)

Silence of the GUCY2C tumor suppressor

Science Translational Medicine, 2016
Excess calories promote colon cancer by silencing a key tumor suppressor.
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Analysis of siRNA-Suppressor of Gene Silencing Interactions

2008
RNA silencing is an evolutionarily conserved system that functions as an antiviral mechanism in higher plants and animals. To counteract RNA silencing, viruses evolved silencing suppressors that interfere with siRNA guided RNA silencing pathway. We used the heterologous Drosophila in vitro embryo RNA to analyze the molecular mechanism of suppression of
Lóránt, Lakatos, József, Burgyán
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CHD5 a tumour suppressor is epigenetically silenced in hepatocellular carcinoma

Liver International, 2014
AbstractBackgroundChromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a potent tumour suppressor by acting as a master regulator of a tumour‐suppressive network. Its inactivation resulted from aberrant methylation in the promoter occurs in several types of human malignancy and is associated with malignant tumour behaviour.
Rui, Zhao, Nisha, Wang, Haili, Huang, Wenli, Ma, Qitao, Yan   +4 more
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Epigenetic Silencing of Tumor Suppressor Genes in Pancreatic Cancer

Journal of Gastrointestinal Cancer, 2011
Without any alteration of DNA sequence, heritable changes in gene expression, caused by epigenetic pathways, are gaining a spotlight in research of diseases, and in particular, cancer. Although the dominant paradigm in cancer research, proposed by Vogelstein, suggested that cancer progression was caused by a sequential accumulation of genetic ...
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Gunshot Residue Deposition With and Without Firearm Suppressors (Silencers)

American Journal of Forensic Medicine & Pathology
Abstract Forensic pathologists recognize the importance of estimating the range of fire for gunshot entrance wounds. Classically described ranges of fire include contact, close range, medium (or intermediate) range, and indeterminate (or distant) range.
Samuel P, Prahlow, Lee, Morgan, Joseph A, Prahlow   +2 more
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Functional analyses of viral RNA silencing suppressors and a strategy to screen antiviral compounds that target viral RNA silencing suppressors

Journal of General Plant Pathology, 2011
RNA silencing is triggered by double-stranded RNAs (dsRNAs), and the dsRNAs are processed into 21to 24-nulceotide (nt) short interfering RNAs (siRNAs) by a host dsRNA-specific ribonuclease, Dicer. The siRNAs are subsequently incorporated into ARGONAUTE (AGO) proteins and serve as a guide for either sequence-specific cleavage or translational repression
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H2AT120 Phosphorylation by VPRBP Silences Tumor Suppressor Genes

Cancer Discovery, 2013
Abstract Vpr binding protein (VPRBP) represses transcription by phosphorylating H2AT120 on nucleosomes.
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Viral Suppressors of Gene Silencing

2021
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Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity

Nature Reviews Immunology, 2021
Filippo Veglia, Dmitry I Gabrilovich
exaly  

RNA Silencing and Viral Encoded Silencing Suppressors

2011
Masato Ikegami, Tatsuya Kon, Pradeep Sharma   +2 more
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