Results 61 to 70 of about 400,021 (291)
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Deciphering the RNA Silencing Suppressor Function in the Potyvirus SPV2 [PDF]
Viruses 2020—Novel Concepts in Virology, 2020 This article belongs to the Proceedings of Viruses 2020—Novel Concepts in Virology.
Ornela Chase +2 more
openaire +3 more sources
Structural study of CUG-repeating small RNAs complexed with silencing suppressor P19 [PDF]
, 2012 The study is focused on structural aspects of interaction between silencing suppressor p19 and CUG-repeating small RNAs. The work involves crystal structure determination of a protein-unbound RNA form and RNA fragments of various lengths (19, 20, 21 ...
Katorcha, Elizaveta
core +2 more sources
Interplays between soil-borne plant viruses and RNA silencing-mediated antiviral defense in roots
Frontiers in Microbiology, 2016 Although the majority of plant viruses are transmitted by arthropod vectors and invade the host plants through the aerial parts, there is a considerable number of plant viruses that infect roots via soil-inhabiting vectors such as plasmodiophorids ...
Ida Bagus Andika +3 more
doaj +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Acquisition of full-length viral helicase domains by insect retrotransposon-encoded polypeptides
Frontiers in Microbiology, 2015 Recent metagenomic studies in insects identified many sequences unexpectedly closely related to plant virus genes. Here we describe a new example of this kind, insect R1 LINEs with an additional C-terminal domain in their open reading frame 2.
Ekaterina eLazareva +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso +5 more
wiley +1 more source
Effect of a silencing suppressor gene towards the expression of VP2 protein of highly virulent infectious bursal disease virus in tobacco [PDF]
Journal of BioScience and Biotechnology, 2013 Gene silencing has been recognized as an important factor, which influence the expression of heterologous protein delivered via plant-viral based system.
Siti-Hasmah Mohtar +3 more
doaj
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Viral Suppressors of Gene Silencing
, 2008 Virus-induced gene silencing and viral suppression of gene silencing was first described in plants using plant poty- and potexviruses. This research began by a few laboratories has burgeoned into a larger field of study surrounding the role of small 21–25 nt RNAs in modulating disease and development. Gene silencing is often referred to as an antiviral
Verchot-Lubicz, J., Carr, J.P.
openaire +1 more source