Results 91 to 100 of about 281,837 (328)

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

Clinical Characteristics and Outcomes of Early‐Onset Versus Late‐Onset LGI1‐Antibody Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Leucine‐rich glioma‐inactivated 1 antibody (LGI1‐Ab) encephalitis predominantly affected older individuals, but has also been reported in younger patients. However, the demographic, clinical, and prognostic characteristics of early‐onset LGI1‐Ab encephalitis have yet to be systematically elucidated. This study aims to systematically
Yu Kong, Shasha Yu, Jing Zhang, Yu Zu, Yujing Zhang, Jing Lv, Xuyang Cao, Xuedan Feng   +7 more
wiley   +1 more source

Silent synapses in pain-related anterior cingulate cortex

Molecular Pain, 2023
Synaptic plasticity such as Long-term potentiation (LTP) is a key mechanism for learning in central synapses including the cortex. There are two least two major forms of LTPs: presynaptic LTP and postsynaptic LTP. For postsynaptic LTP, the potentiation of AMPA receptor-mediated responses through protein phosphorylation is thought to be a key mechanism.
openaire   +2 more sources

Amyloid fibrils induce dysfunction of hippocampal glutamatergic silent synapses [PDF]

Hippocampus, 2018
AbstractSilent glutamatergic synapses lacking functional AMPA (α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazoleproprionate) receptors exist in several brain regions including the hippocampus. Their involvement in the dysfunction of hippocampal glutamatergic transmission in the setting of Alzheimer's disease (AD) is unknown.
Bihua Bie, Jiang Wu, Joseph F. Foss, Mohamed Naguib   +3 more
openaire   +2 more sources

Building a realistic, scalable memory model with independent engrams using a homeostatic mechanism

Frontiers in Neuroinformatics
Memory formation is usually associated with Hebbian learning and synaptic plasticity, which changes the synaptic strengths but omits structural changes.
Marvin Kaster, Fabian Czappa, Markus Butz-Ostendorf, Markus Butz-Ostendorf, Felix Wolf   +4 more
doaj   +1 more source

New Tools for Investigating Astrocyte-to-Neuron Communication

Frontiers in Cellular Neuroscience, 2013
Grey matter protoplasmic astrocytes extend very thin processes and establish close contacts with synapses. It has been suggested that the release of neuroactive gliotransmitters at the tripartite synapse contributes to information processing.
Dongdong eLi, Cendra eAgulhon, Elke eSchmidt, Martin eOheim, Nicole eRopert   +4 more
doaj   +1 more source

An Online Unsupervised Structural Plasticity Algorithm for Spiking Neural Networks

, 2015
In this article, we propose a novel Winner-Take-All (WTA) architecture employing neurons with nonlinear dendrites and an online unsupervised structural plasticity rule for training it.
Basu, Arindam, Roy, Subhrajit
core   +1 more source

Associative memory of phase-coded spatiotemporal patterns in leaky Integrate and Fire networks [PDF]

, 2012
We study the collective dynamics of a Leaky Integrate and Fire network in which precise relative phase relationship of spikes among neurons are stored, as attractors of the dynamics, and selectively replayed at differentctime scales.
Giacco, Ferdinando, Scarpetta, Silvia
core   +2 more sources

PKN1 promotes synapse maturation by inhibiting mGluR-dependent silencing through neuronal glutamate transporter activation

Communications Biology, 2020
Abnormal metabotropic glutamate receptor (mGluR) activity could cause brain disorders; however, its regulation has not yet been fully understood. Here, we report that protein kinase N1 (PKN1), a protein kinase expressed predominantly in neurons in the ...
H. Yasuda, Hikaru Yamamoto, K. Hanamura, Mona Mehruba, T. Kawamata, Hiromi Morisaki, M. Miyamoto, S. Takada, T. Shirao, Y. Ono, H. Mukai   +10 more
semanticscholar   +1 more source

ALS With and Without Upper Motor Neuron Signs: A Comparative Study Supporting the Gold Coast Criteria

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung, E‐nae Cheong, Jungmin So, Heung‐Won Kang, Yangsean Choi, Eun‐Jae Lee, Hyunjin Kim, Young‐Min Lim   +7 more
wiley   +1 more source