Results 51 to 60 of about 4,863 (192)
IL-6 mediates platinum-induced enrichment of ovarian cancer stem cells [PDF]
, 2018 In high-grade serous ovarian cancer (OC), chemotherapy eliminates the majority of tumor cells, leaving behind residual tumors enriched in OC stem cells (OCSC).
Berek +10 more
core +1 more source
A new approach to the management of COVID-19. Antagonists of IL-6: Siltuximab [PDF]
, 2022 Since the beginning of the pandemic, numerous national and international clinical trials have been conducted with a large number of drugs. Many of them are intended for the treatment of other pathologies; however, despite the great effort made, no ...
Gayo Abeleira, Irene +3 more
core +1 more source
Modeling anti-IL-6 therapy using breast cancer patient-derived xenografts [PDF]
, 2016 The pleiotropic cytokine IL-6 accelerates the progression of breast cancer in a variety of preclinical models through the activation of the STAT3 (signal transducer and activator of transcription 3) signaling pathway.
Arribas, Joaquín V. (Vicente) +8 more
core +1 more source
Salvaging the septic heart through targeting the IL-6/p38 MAPK signaling network [PDF]
, 2018 Depression of myocardial function during severe sepsis, which currently accounts for approx. 200,000 deaths/year in the United States (1), is characterized by a decrease in contractility and a poor response to fluid therapy (2). Since the md-1980s it has
Cannell, Ian G., Yaffe, Michael B
core +1 more source
Case Reports in Hematology, 2022 RationalCastleman disease is a rare lymphoproliferative disorder that can be subdivided into unicentric and multicentric forms, the latter of which causes a spectrum of serious medical conditions.
Stamatios Chrysochoou +2 more
doaj +1 more source
STAT3 regulated ARF expression suppresses prostate cancer metastasis. [PDF]
, 2015 Prostate cancer (PCa) is the most prevalent cancer in men. Hyperactive STAT3 is thought to be oncogenic in PCa. However, targeting of the IL-6/STAT3 axis in PCa patients has failed to provide therapeutic benefit. Here we show that genetic inactivation of
Aberger, Fritz +40 more
core +3 more sources
The role of cytokines in ovarian cancer drug resistance
International Journal of Cancer, Volume 158, Issue 4, Page 821-834, 15 February 2026.Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Lu Wang +7 more
wiley +1 more source
A Novel Humanized Anti-Interleukin-6 Antibody HZ0408b With Anti-Rheumatoid Arthritis Therapeutic Potential [PDF]
, 2022 Interleukin-6 (IL-6), a pleiotropic cytokine that regulates immune responses and inflammatory reactions, plays a pivotal role in the development of rheumatoid arthritis (RA).
Guo, Fei +8 more
core +1 more source
Population pharmacokinetics of siltuximab: impact of disease state
Cancer Chemotherapy and Pharmacology, 2019 To characterize the effects of disease type and clinical characteristics on the pharmacokinetics of siltuximab, an IL-6 inhibiting monoclonal antibody.Siltuximab pharmacokinetic data were combined from seven phase I/II clinical trials. A population pharmacokinetic model was developed to characterize changes in siltuximab disposition with disease type ...
Mina Nikanjam +2 more
openaire +3 more sources
Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren +4 more
wiley +1 more source