Results 71 to 80 of about 4,863 (192)

Redefining Cure in Multiple Myeloma: Are We Chasing a Moving Target?

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Multiple myeloma (MM), a clonal plasma cell malignancy, remains incurable despite significant therapeutic advances, including novel immunotherapies like chimeric antigen receptor T‐cell (CAR‐T) therapy and bispecific antibodies.
Jacob Henry Kitundu
wiley   +1 more source

Anti-IL6 Autoantibodies in an Infant With CRP-Less Septic Shock

Frontiers in Immunology, 2019
Background: Interleukin-6 (IL-6) is a pleiotropic cytokine with a multitude of pro-inflammatory effects. Serum C-reactive protein (CRP) is an acute phase protein induced mainly by IL-6 in response to inflammatory conditions, particularly infection.
Marketa Bloomfield, Marketa Bloomfield, Zuzana Parackova, Tamara Cabelova, Iva Pospisilova, Iva Pospisilova, Pavel Kabicek, Hana Houstkova, Anna Sediva   +8 more
doaj   +1 more source

TAFRO Syndrome Mimicking Solid Cancer and Successfully Treated by Tocilizumab: A Case and Literature Review

Journal of Cancer Research and Practice, 2023
TAFRO syndrome, or now formally termed idiopathic multicentric Castleman disease (iMCD) with thrombocytopenia, anasarca, fever, renal insufficiency or reticulin fibrosis, and organomegaly (iMCD-TAFRO), describes a unique subtype of iMCD.
Pei-An Fu, Chia-Chi Wu, Ya-Ting Hsu
doaj   +1 more source

Scanning for therapeutic targets within the cytokine network of idiopathic inflammatory myopathies [PDF]

, 2015
The idiopathic inflammatory myopathies (IIM) constitute a heterogeneous group of chronic disorders that include dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis (IBM) and necrotizing autoimmune myopathy (NAM).
De Paepe, Boel, Zschüntzsch, Jana
core   +3 more sources

Therapy of Castleman’s disease with siltuximab – case report and review of literature

Klinicka onkologie, 2023
Idiopathic multicentric Castleman disease (iMCD) is characterized by constitutional symptoms, enlarged lymph nodes and laboratory test abnormalities, which are primarily related to the overproduction of interleukin-6 (IL-6). This form (iMCD) was treated earlier with cytostatics used for lymphoma, later with bio-logic therapy as rituximab ...
Z, Adam, D, Zeman, A, Chodacki, L, Pour, T, Horváth, P, Benda, Z, Adamová, M, Krejčí, M, Tomíška, I, Boichuk, Z, Král   +10 more
openaire   +2 more sources

Clinical Presentation, Treatment, and Outcomes of 28 Patients With Castleman Disease: A Retrospective Analysis of an Italian Cohort

eJHaem, Volume 6, Issue 6, December 2025.
ABSTRACT Background Castleman disease (CD) encompasses a range of heterogeneous non‐clonal lymphoproliferative disorders, including unicentric (UCD), and multicentric (MCD) forms. The latter is subdivided into HHV‐8+ MCD, POEMS‐MCD, and idiopathic‐MCD, not otherwise specified (iMCD‐NOS).
Caterina Cristinelli, Michele Merli, Marco Lucioni, Manuel Gotti, Roberta Sciarra, Sara Rattotti, Federico Carpi, Gianmarco Favrin, Benedetta Bianchi, Giuseppe Neri, Marta Coscia, Marcello Gambacorta, Francesco Passamonti, Marco Paulli, Luca Arcaini   +14 more
wiley   +1 more source

Autoimmunity and COPD: clinical implications. [PDF]

, 2017
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Long term cigarette smoking is the cause of more than 90% of COPD in Westernized countries.
Amatya, Antonino Di Stefano, Barnes, Blum, Born, Caramori, Cheng, Cooper, Cosio, Cosio, Craig, Daffa, Di Stefano, Di Stefano, Durham, Dörner, Eich, Feghali-Bostwick, Gaetano Caramori, Ganusov, Ghosh, Giuseppe Girbino, Guerreiro Castro, Hennes, Hodge, Hodge, Hoe, Hogg, Ian M. Adcock, John-Schuster, Kanoh, Kirkham, Korn, Kuhn, Kunz, Kurschus, Lee, Lobo, Luo, Moreno Torres, Morissette, Motz, Motz, Ni, Núñez, Paolo Ruggeri, Paul Kirkham, Pitzalis, Polverino, Roos, Schroeder, Seys, Sharon Mumby, Steri, Sullivan, Westermann, Wong, Xiong, Yadava   +58 more
core   +1 more source

Siltuximab (CNTO 328): a promising option for human malignancies

Drug Design, Development and Therapy, 2015
Runzhe Chen, Baoan Chen Department of Hematology and Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing, Jiangsu Province, People’s Republic of China Abstract: Siltuximab (CNTO 328) is a promising antibody-drug ...
Chen R, Chen B
doaj  

Present and future treatment strategies for coronavirus disease 2019

Future Journal of Pharmaceutical Sciences, 2021
Background The recent pandemic of coronavirus disease 2019 (COVID-19) has resulted in many challenges to the healthcare organizations around the world. Unfortunately, until now, there are no proven effective therapeutic agents against this virus.
Engy Elekhnawy, Amal Abo Kamar, Fatma Sonbol   +2 more
doaj   +1 more source

Monocyte Phenotype and IFN-γ-Inducible Cytokine Responses Are Associated with Cryptococcal Immune Reconstitution Inflammatory Syndrome. [PDF]

, 2017
A third of adults with AIDS and cryptococcal meningitis (CM) develop immune reconstitution inflammatory syndrome (IRIS) after initiating antiretroviral therapy (ART), which is thought to result from exaggerated inflammatory antigen-specific T cell ...
Bohjanen, Paul R, Boulware, David R, Cose, Stephen, Janoff, Edward N, Joloba, Moses, Mayanja-Kizza, Harriet, Meya, David B, Okurut, Samuel, Wahl, Sharon, Yukari Manabe, Carol, Zziwa, Godfrey   +10 more
core   +1 more source