Results 81 to 90 of about 4,863 (192)

TAFRO Syndrome: Guidance for Managing Patients Presenting Thrombocytopenia, Anasarca, Fever, Reticulin Fibrosis, Renal Insufficiency, and Organomegaly

Biomedicines
TAFRO syndrome is an inflammatory disorder of unknown etiology characterized by thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly. Despite great advancements in research on the TAFRO syndrome in the last decade,
Katsuhiro Miura, Haruna Nishimaki-Watanabe, Hiromichi Takahashi, Masaru Nakagawa, Shimon Otake, Takashi Hamada, Takashi Koike, Kazuhide Iizuka, Yuuichi Takeuchi, Kazuya Kurihara, Toshihide Endo, Shun Ito, Hironao Nukariya, Takahiro Namiki, Yoshiyuki Hayashi, Hideki Nakamura   +15 more
doaj   +1 more source

IL-6–targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function

JCI Insight, 2022
Therapeutics that inhibit IL-6 at different points in its signaling pathway are in clinical use, yet whether the immunological effects of these interventions differ based on their molecular target is unknown.
Cate Speake, Tania Habib, Katharina Lambert, Christian Hundhausen, Sandra Lord, Matthew J. Dufort, Samuel O. Skinner, Alex Hu, MacKenzie Kinsman, Britta E. Jones, Megan D. Maerz, Megan Tatum, Anne M. Hocking, Gerald T. Nepom, Carla J. Greenbaum, Jane H. Buckner   +15 more
doaj   +1 more source

Emerging agents and regimens for multiple myeloma

Journal of Hematology & Oncology, 2020
The outcomes of multiple myeloma (MM) have been improved significantly with the therapies incorporating proteasome inhibitors (PI), immunomodulatory drugs, monoclonal antibodies (MoAb) and stem cell transplantation.
Yang Yang, Yi Li, Huiyao Gu, Mengmeng Dong, Zhen Cai   +4 more
doaj   +1 more source

Reprogrammed MDSCs promote Th1‐dominant antitumour response via CD40 induced by autocrine TNF‐α after combining cryo‐thermal therapy with IL6 and IL17A neutralization

Clinical and Translational Medicine, Volume 15, Issue 10, October 2025.
The combination of IL‐6 and IL‐17A neutralizing antibodies and cryo‐thermal therapy promotes the expression of CD40 on MDSCs by inducing TNF‐α production via the NF‐κB pathway in MDSCs. The CD40–CD40L interaction initiates the Th1‐dominant differentiation of CD4+ T cells, leading to long‐term antitumour immunity.
Yuankai Hao, Shicheng Wang, Junjun Wang, Zelu Zhang, Yichen Yao, Ke Wang, Ping Liu, Lisa X. Xu   +7 more
wiley   +1 more source

Identification and manipulation of tumor associated macrophages in human cancers [PDF]

, 2011
Evading immune destruction and tumor promoting inflammation are important hallmarks in the development of cancer. Macrophages are present in most human tumors and are often associated with bad prognosis.
A Algars, A Corthay, A Mantovani, A Mantovani, A Mantovani, A Puig-Kroger, A Rigo, A Takahashi, A Terlou, A Tzankov, AM Figel, B Caillou, BM Burt, BZ Qian, C Bailey, C Lonnroth, C Murdoch, C Porta, C Steidl, C van Kooten, CH Lee, CJ Melief, CM Ohri, CM Ohri, D Azambuja, D Duluc, D Hanahan, D Kabelitz, D Nagorsen, D Niino, D Pilling, D Wang, DG DeNardo, DG DeNardo, DI Gabrilovich, DM Kuang, DM Kuang, DM Mosser, E Choy, E Schmitt, E Zeni, EM Verdegaal, ES Jordanova, F Avila-Moreno, F Pages, F Porcheray, FA Verreck, FO Martinez, FO Martinez, GL Beatty, H Dalwadi, H Hasita, H Kurahara, H Roca, H Takayama, H Van Gorp, H Yu, HJ Zijlmans, I Espinosa, I Kryczek, I Kryczek, I Shabo, IH Bronkhorst, J Chen, J Coward, J Forssell, J Gadiot, J Ma, J Pander, J Zhang, JA Webster, JC Kang, JR Brown, JS Pettersen, K Kawamura, K Movahedi, L Apetoh, L Bingle, L Sanchez-Martin, LS Hammes, M Herfs, M Heusinkveld, M Ryder, M van Dongen, MB Maniecki, MD Martin, MH McLean, MJ Campbell, MJ Edelman, MJ Welters, MM Tiemessen, Moniek Heusinkveld, N Nonomura, N Obermajer, NN Hunder, PJ de Vos van Steenwijk, PJ Murray, R Bos, R Karim, RB Mailliard, RD Stout, RD Stout, RM Steinman, RS Freedman, S Banerjee, S Gordon, S Osinsky, S Wirths, SJ Piersma, Sjoerd H van der Burg, SK Biswas, T Krausgruber, T Kreider, T Lawrence, TJ Curiel, TO Jensen, W Xu, X Yang, Y Komohara, Y Nakanishi, YS Shieh   +120 more
core   +3 more sources

Ethical Implications of the Mild Encephalitis Hypothesis of Schizophrenia [PDF]

, 2017
Schizophrenia is a serious mental disease with a high mortality rate and severe social consequences. Due to insufficient knowledge about its etiopathogenesis, curative treatments are not available.
Mueller, Sabine, Riedmueller, Rita
core   +1 more source

From Bench to Clinic: Advances in Anti‐Inflammatory Therapies for Atherosclerotic Coronary Artery Disease

The FASEB Journal, Volume 39, Issue 18, 30 September 2025.
The changing face of AS. This diagram illustrates the research landscape of ASCAD. It highlights a shift in understanding from viewing it as a lipid storage disease to recognizing it as a chronic inflammatory disease. Additionally, emerging therapies like colchicine, methotrexate, IL‐1 blockade, IL‐6 blockade, darapladib, and low‐dose IL‐2 are being ...
Kan Wang, Zheng Yin, Yang Zhang, Xianpeng Wu, Lin Fan   +4 more
wiley   +1 more source

A systematic review and meta-analysis of Anakinra, Sarilumab, Siltuximab and Tocilizumab for Covid-19 [PDF]

, 2020
Background There is accumulating evidence for an overly activated immune response in severe Covid-19, with several studies exploring the therapeutic role of immunomodulation.
Fabbri, Laura, Fabbri, Laura, Jenkins, Gisli, Khan, Fasihul, Moss, Samuel, Moss, Samuel, Robinson, Karen, Smyth, Alan, Stewart, Iain   +8 more
core   +1 more source

International Consensus Histopathological Criteria for Subtyping Idiopathic Multicentric Castleman Disease Based on Machine Learning Analysis

American Journal of Hematology, Volume 100, Issue 9, Page 1502-1512, September 2025.
ABSTRACT Idiopathic multicentric Castleman disease (iMCD) is a rare lymphoproliferative disorder classified into three recognized clinical subtypes—idiopathic plasmacytic lymphadenopathy (IPL), TAFRO, and NOS. Although clinical criteria are available for subtyping, diagnostically challenging cases with overlapping histopathological features highlight ...
Midori Filiz Nishimura, Tomoka Haratake, Yoshito Nishimura, Asami Nishikori, Remi Sumiyoshi, Hideki Ujiie, Yuri Kawahara, Tomohiro Koga, Masao Ueki, Dorottya Laczko, Eric Oksenhendler, David C. Fajgenbaum, Frits van Rhee, Atsushi Kawakami, Yasuharu Sato   +14 more
wiley   +1 more source

Impact of siltuximab on patient-related outcomes in multicentric Castleman’s disease

Patient Related Outcome Measures, 2018
Jenna Sitenga,1 Gregory Aird,1 Aabra Ahmed,1 Peter T Silberstein2 1Division of Education, Creighton University School of Medicine, Omaha, NE, USA; 2Division of Hematology/Oncology, Creighton University School of Medicine, Omaha, NE, USA Abstract ...
Sitenga J, Aird G, Ahmed A, Silberstein PT   +3 more
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